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八物君子湯이 Cytochrome P450 酵素 활성에 미치는 영향

The Effects of Palmulgunja-tang(八物君子湯) Enzyme Activity on Cytochrome P450 Isozyme

박성식|류정만
사상체질면역의학회 (The Society of Sasang Constitution and Immune Medicine)|2005.08|사상체질면역의학회지 (Journal of Sasang Constitution and Immune Medicine)|제17권 제2호|pp. 64-73

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초록

Abstract

1. Objectives The purpose of this study was to investigate the effects of the enzyme activity of Palmulgunja-tang with administered orally solution on cytochrome P450 isozyme 2. Methods This study was carried on through following methods. We treated the rat with the β-naphthoflavone (βNF) of 80㎎/kg for 3 days i.p injection. Firstable, microsomal protein was separated and total intracellular protein test was done. Then GOT and GPT were measured and assay of cytochrome P450 1A1/2 enzyme activity was performed according to the method of EROD and MROD. (Ethoxyresorufin-O-deethylase(EROD) activity was used to measure cytochrome P450 1A1 activity and  methoxyresorufin O-demethylase(MROD) activity was used to measure  cytochrome P450 1A2 activity. ) 3. Results and Conclusions 1) PGT recovered the liver damage on βNF inducible CYP 1A1/2 by pre-post and high-low condition. 2) At concentration of post-treated 50㎎/kg of PGT, the inhibiting of βNF metabolites to liver of rat cytochrome P450 1A1 was inhibited by 53.0% respectively. 3) PGT showed 36.0% inhibition of βNF-induced 1A2 activity at the concentration post-treated 50㎎/kg.

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