Gene expression patterns of Etv5 and Etv6 in molar tooth germs at the cap stage
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The Fgf signaling pathway plays an important role in the sequential process of tooth development and morphogenesis. Ets (E-twenty-six) is a family of transcription factors regulated by the Fgf signaling pathway and is involved in the development of various organs. Although most Ets proteins act as transcriptional activators, Etv5 (Ets version 5) and Etv6 (Ets version 6) reportedly act as transcriptional repressors. Expression of Etv5 mRNA has been reported in developing teeth, whereas Etv6 expression has not been reported yet. In this study, we examined the expression pattern of Etv6 in tooth development and compared the expression patterns of Etv5 and Etv6. Etv5 was strongly expressed in epithelium, except in the enamel knot, while Etv6 was strongly expressed in dental lamina and stellate reticulum. Although their expression patterns overlapped in the stellate reticulum, there were many differences overall. This result suggests that Etv5 and Etv6 regulate different genes.
Abstract
The Fgf signaling pathway plays an important role in the sequential process of tooth development and morphogenesis. Ets (E-twenty-six) is a family of transcription factors regulated by the Fgf signaling pathway and is involved in the development of various organs. Although most Ets proteins act as transcriptional activators, Etv5 (Ets version 5) and Etv6 (Ets version 6) reportedly act as transcriptional repressors. Expression of Etv5 mRNA has been reported in developing teeth, whereas Etv6 expression has not been reported yet. In this study, we examined the expression pattern of Etv6 in tooth development and compared the expression patterns of Etv5 and Etv6. Etv5 was strongly expressed in epithelium, except in the enamel knot, while Etv6 was strongly expressed in dental lamina and stellate reticulum. Although their expression patterns overlapped in the stellate reticulum, there were many differences overall. This result suggests that Etv5 and Etv6 regulate different genes.
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