Aldh1a2 is a maker of dental follicle in tooth germs at cap stage
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Retinoic acid is an important signaling molecule in animal development. Deficiency of retinoic acid causes loss of teeth and skull deformity. In the early stages of tooth development, retinoic acid has been reported to regulate tooth morphology. The major enzymes of retinoic acid formation, Aldh1a2 and Aldh1a3, are expressed during tooth development. However, no expression pattern of the two genes was reported for each tooth development stage. In this study, we examined the expression patterns of Aldh1a2 and Aldh1a3 genes in the tooth germ at cap stage. Aldh1a2 showed strong expression only in the dental follicle of the tooth germ, but Aldh1a3 expression was weakly observed throughout the tooth germ. Aldh1a2 could be used as a new marker of dental follicle.
Abstract
Retinoic acid is an important signaling molecule in animal development. Deficiency of retinoic acid causes loss of teeth and skull deformity. In the early stages of tooth development, retinoic acid has been reported to regulate tooth morphology. The major enzymes of retinoic acid formation, Aldh1a2 and Aldh1a3, are expressed during tooth development. However, no expression pattern of the two genes was reported for each tooth development stage. In this study, we examined the expression patterns of Aldh1a2 and Aldh1a3 genes in the tooth germ at cap stage. Aldh1a2 showed strong expression only in the dental follicle of the tooth germ, but Aldh1a3 expression was weakly observed throughout the tooth germ. Aldh1a2 could be used as a new marker of dental follicle.
참고문헌 (19)
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