치아 발생과정 중 각 시기와 치아부위에 따른 주요 유전자의 발현 양의 비교
Comparison of Time Curse Gene Expression Levels in Developing Tooth Germ
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The meaningful genes related to tooth development are known as 300. The observation of timeOcourse pattems of them is possible to predict the gene interactions. In this study, we focused on 12 meaningful genes in developing tooth gelm such as Fgf8, Bmp4, Lhx6, Pax9, Barx1, Msx1, Msx2, Shh, Ptc, Gli3, Lef4，Activin-ba Theses genes are related to the epithelial-mesenchymal interaction. We perforrned real-time Quantitative PCR for confirrn the gene expression level of each gene from embryonic day 10.5 to 16.5. The application of the expression level and approaching method has demonstrated the useful of the guidelines for research of gene interaction during tooth development.
Abstract
The meaningful genes related to tooth development are known as 300. The observation of timeOcourse pattems of them is possible to predict the gene interactions. In this study, we focused on 12 meaningful genes in developing tooth gelm such as Fgf8, Bmp4, Lhx6, Pax9, Barx1, Msx1, Msx2, Shh, Ptc, Gli3, Lef4，Activin-ba Theses genes are related to the epithelial-mesenchymal interaction. We perforrned real-time Quantitative PCR for confirrn the gene expression level of each gene from embryonic day 10.5 to 16.5. The application of the expression level and approaching method has demonstrated the useful of the guidelines for research of gene interaction during tooth development.