포화지방산의 탄소사슬 수와 항암 및 항산화작용과의 관계
The Relationship between Carbochain Numbers and Antitumor/Antioxidant of Saturated Fatty Acids
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For the comparison of relationship between carbochain length, anticancer and antioxidant reaction of saturated fatty acids, after choosing 8 carbochain caprylic acid, 12 carbochain lawic acid, 16 carbochain p머mitic acid and 18 carbochain stearic acid, they were adapted to NIH3T3 fibroblasts and human skin melanoma cells and human oral epithelioid carcinoma cell for observating cell existence rate and anti-oxidazing capacity and optic reservation of cells. The results were as follow: 1. Each saturated fatty acid reduced MTT absorbance rate of concentration in dependent manner in NIH3T3 fibroblasts. Lawic acid, palrr디c acid and stearic acid did not show similar difference statistically, but caprylic acid showed statistically simil따difference in 100 UM (p<O.01) 2. To human skin melanoma cell, each saturated fatty acid reduced MTT absorbance rate of concentration dependently. And caprylic acid did not show simi때 difference statistically, but, lawic acid, palmitic acid and stearic acid showed simi밟difference. Cell survival rate was reduced by carbochain length 3. To human or려 epithelioid carcinoma cell, each saturated fatty acid reduced MTT absorbance of concentration dependently caprylic acid showed similar difference statistically in 100 마1， p떠 mitic acid and stearic acid in 50 uM. 4. The rankage of IC잉 concentration in NIH3T3 fibroblasts was caprylic acid < lauric acid < palmitic acid < stearic acid. And the rankage of ICso concentration in human skin melanoma cell and oral epithelioid carcinoma cell was caprylic a띠d > lawic acid > palmitic acid > stearic acid. 5. The rankage of enlargement in DPPH radical scavenging activity of each fatty acid was caprylic acid < lawic acid < palmitic acid < stearic acid 6. The reduction in cell number and morphological change in NIH3T3 fibroblasts were ranked as stearic acid < p머mitic acid < lawic acid < caprylic acid. And also, those in human skin melanoma cell and human or머 epitheloid carcinoma cell were ordered as stearic acid > palmitic acid > lawic acid > caprylic acid. According the results, it was known that carbochain length of fatty acid has close relationship in anticancer reaction and antioxidizing reaction.
Abstract
For the comparison of relationship between carbochain length, anticancer and antioxidant reaction of saturated fatty acids, after choosing 8 carbochain caprylic acid, 12 carbochain lawic acid, 16 carbochain p머mitic acid and 18 carbochain stearic acid, they were adapted to NIH3T3 fibroblasts and human skin melanoma cells and human oral epithelioid carcinoma cell for observating cell existence rate and anti-oxidazing capacity and optic reservation of cells. The results were as follow: 1. Each saturated fatty acid reduced MTT absorbance rate of concentration in dependent manner in NIH3T3 fibroblasts. Lawic acid, palrr디c acid and stearic acid did not show similar difference statistically, but caprylic acid showed statistically simil따difference in 100 UM (p<O.01) 2. To human skin melanoma cell, each saturated fatty acid reduced MTT absorbance rate of concentration dependently. And caprylic acid did not show simi때 difference statistically, but, lawic acid, palmitic acid and stearic acid showed simi밟difference. Cell survival rate was reduced by carbochain length 3. To human or려 epithelioid carcinoma cell, each saturated fatty acid reduced MTT absorbance of concentration dependently caprylic acid showed similar difference statistically in 100 마1， p떠 mitic acid and stearic acid in 50 uM. 4. The rankage of IC잉 concentration in NIH3T3 fibroblasts was caprylic acid < lauric acid < palmitic acid < stearic acid. And the rankage of ICso concentration in human skin melanoma cell and oral epithelioid carcinoma cell was caprylic a띠d > lawic acid > palmitic acid > stearic acid. 5. The rankage of enlargement in DPPH radical scavenging activity of each fatty acid was caprylic acid < lawic acid < palmitic acid < stearic acid 6. The reduction in cell number and morphological change in NIH3T3 fibroblasts were ranked as stearic acid < p머mitic acid < lawic acid < caprylic acid. And also, those in human skin melanoma cell and human or머 epitheloid carcinoma cell were ordered as stearic acid > palmitic acid > lawic acid > caprylic acid. According the results, it was known that carbochain length of fatty acid has close relationship in anticancer reaction and antioxidizing reaction.