반복측정한 임상 데이터의 분석방법에 대한 선발의 연구

Abstract

Data from repeated measurements are accomplished through repeatedly processing the same subject under different conditions and different points of view. The power of testing enhances the choice of pertinent analysis methods that agrees with the characteristics of data concerned and the situation involved. Along with the clinical example, this paper compares the analysis of the variance on ex-post tests, gain score analysis, analysis by mixed design and analysis of covariance employable for repeating measure. Comparing the analysis of variance on ex post test, and gain score analysis on correlations, leads to the fact that the latter enhances the power of the test and diminishes the variance of error terms. The concluded probability, identified that the gain score analysis and the mixed design on interaction between “between subjects factor” and “within subjects factor”, are identical. The analysis of covariance, demonstrated better power of the test and smaller error terms than the gain score analysis. Research on four analysis method found that the analysis of covariance is the most appropriate in clinical data than two repeated test with high correlation and ex ante affects ex post.