관상동맥질환 환자에 있어서 음주，흡연 및 운동이 호모시스테인，엽산 그리고 C- 반응성 단백의 레벨에 미치는 영향

Abstract

This study was carried out to investigate the effects of drinking, smoking and exercise on homocysteine, folate and the C reactive protein in patients with coronaη artery disease. A total of 50 subjects (male; 37, female; 13) with coronary artery disease was assigned to patient group. The normal control group consisted of 33 subjects (male; 21, female; 12) without a history of metabolic or cardiovascular disease. Body mass index (BMI) , blood pressure, and concentration of blood homocysteine, fl이ate， C-reactive protein (CRP) , and lipids were analyzed to determine the effect of drinking, smoking and exercise on those parameters related to coronary artery disease. Concentrations of CRP (p<0.001), total cholesterol (p<0.001), triglyceride (p<0.005), HDLcholesterol (p<0.002) and LDL-cholesterol (p<0.04) were significantly higher in the patient group. It was also shown that one of either homocysteine, folate, or CRP levels has a direct relationship with habit. Among the three habits, smoking played the worst role in folate and CRP levels in the patient group. Homocysteine and CRP (p<0.001) concentrations were increased and the folate concentration (p<0.05) was decreased in the smoking group. These results suggest that smoking makes matters of coronary artery disease worse; therefore, it would be critical for patients with coronary artery disorder to quit smoking.