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MTHFR 677유전자형과 복합운동이 남자 대학생들의 호모시스테인 농도에 미치는 영향

Combined Training Effects on Homocysteine Levels in Male College Students according to MTHFR 677 Polymorphism

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초록

이 연구의 목적은 심폐체력, 심혈관질환 위험요인과 식이섭취가 호모시스테인의 농도에 미치는 영향을 알아보고, MTHFR 유전자 다형성과 복합운동에 따른 호모시스테인의 농도변화를 알아보는 데 있다. 이 연구는 62명의 건강한 남자 대학생(24.50±1.84세)을 대상으로 실시하였으며, 12주간 주 4회의 중․고강도의 유산소운동(70%VO2R)과 저항운동(8~12RM)을 병행한 복합운동을 실시하였다. 심폐체력, 심혈관질환 위험요인과 식이섭취는 호모시스테인의 농도에 유의한 영향을 주지 않는 것으로 나타났다. 반면, MTHFR 유전자 다형성에 따른 호모시스테인 농도는 운동 전 유의한 차이를 나타내었으며, TT 유전자형 집단이 CC 유전자형(p<.001)과 CT 유전자형 집단(p<.001)보다 유의하게 높은 혈중 호모시스테인 농도를 나타내었다. 12주간 운동훈련 후 체질량지수의 변화가 측정시기와 유전자형 집단의 상호작용 효과를 나타내었으며(p<.05), 호모시스테인의 농도도 유전자형 집단(p<.05) 및 측정시기와 유전자형 집단의 상호작용 효과를 나타내었다(p<.01). 따라서 건강한 남자 대학생들의 경우 심폐체력, 심혈관질환 위험요인 및 식이섭취는 호모시스테인 농도에 유의한 영향을 주지 않는 것으로 나타났다. 또한, 호모시스테인 농도는 MTHFR 유전자형에 따라 차이를 나타내는 것으로 나타났으며, 운동훈련에 따른 변화에도 영향을 주는 것으로 나타났다.

Abstract

The purpose of this study was to investigate the association between cardiorespiratory fitness, cardiovascular risk factors, dietary habits and homocysteine level in male college students. Also, this study was to investigate the combined training effects on homocysteine levels in male college students according to MTHFR 677 polymorphism. The subjects who participated in this study were 62 healthy male college students(24.50±1.84yrs). All subjects participated in the supervised training program for 12 weeks(4days a week) consisting of aerobic exercise(70% VO2R, 50minutes a day) and resistance training(8~12 RM, 3sets). We did not find any association among cardiorespiratory fitness, cardiovascular risk factors, dietary habits and homocysteine level. Mean values of plasma homocysteine level were significantly higher in the TT genotype group compared to the CC and CT genotype in baseline(p<.001). After exercise training, it was shown that body mass index(p<.05) and plasma homocysteine levels(p<.001) significantly interaction effect between time and group. No change occurred in total cholesterol, high density lipoprotein cholesterol, or triglycerides. Consequently, there were no significant relationships among plasma homocysteine and cardiovascular risk factor, dietary habits and cariorespiratory fitness. However, our results indicate that MTHFR 677 gene affected plasma homocysteine level at baseline and the changes of homocysteine level after combined exercise training.

참고문헌 (54)

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