고혈압자의 고중성지방혈증-허리 표현형과 대사이상 사이의 연관성
Association between Hypertriglyceridemic-Waist Phenotype and Metabolic Abnormalities in Hypertensive Adults
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초록
고중성지방혈증-허리(hypertriglyceridemic-waist, HTGW) 표현형은 관상동맥질환 위험을 예측하는 것으로 알려져 있다. 본 연구는 고혈압자를 대상으로 HTGW 표현형과 대사이상 사이의 관련성을 평가하였다. 경기지역 종합병원에서 2018년 1 월부터 2021년 12월까지 건강검진을 실시한 20세 이상 성인 고혈압자를 대상으로 단면연구를 시행하였다. HTGW 표현형은중성지방 농도 ≥150 mg/dL, 허리둘레 남성 ≥90 cm, 여성 ≥ 85 cm로 정의되었다. 본 연구대상자의 HTGW 표현형 유병률은 17.9%였다. 연령과 성별, 체질량지수를 보정한 후 HTGW군의 위험비는 NTNW군과 비교하여 낮은 고밀도 지단백 콜레스테롤은 5.09 (95% 신뢰구간, 95% confidence interval [95% CI]: 3.545∼7.309), 높은 저밀도 지단백 콜레스테롤은 1.68 (95% CI: 1.176∼2.411), 높은 총콜레스테롤은 2.92 (95% CI: 2.009∼4.235), 당뇨병은 3.39 (95% CI: 2.124∼5.412), 고요산혈증은 1.85 (95% CI: 1.286∼2.674)이었다. 대사증후군을 진단하기 위한 HTGW 표현형의 곡선하 면적값은 전체 대상자 0.849, 남성 0.858, 여성 0.890로 나타났다. 결론적으로HTGW 표현형은 대사이상과 밀접한 관련이 있으며, 대사증후군이 있는 성인 고혈압자의 모니터링에 유용한 지표였다.
Abstract
The hypertriglyceridemic-waist (HTGW) phenotype can predict the risk of coronary artery disease. This study evaluated the relationship between the HTGW phenotype and metabolic abnormalities in hypertensive adults. The test was conducted on adult hypertension patients aged 20 or older who underwent health checkups from January 2018 to December 2021 at general hospitals in Gyeonggi Province. The HTGW phenotype was triglyceride ≥150 mg/dL and waist circumference ≥90 cm for men and ≥85 cm for women. The prevalence of the HTGW phenotype in the study subjects was 17.9%. After adjusting for age, gender, and BMI, the odds ratio of the HTGW group was 5.09 (95% confidence interval [CI]: 3.545∼7.309) for low HDL-cholesterol, 1.68 (95% CI: 1.176∼2.411) for high LDL-cholesterol, was 2.92 (95% CI: 2.009∼4.235) for high total cholesterol, 3.39 (95% CI: 2.124∼5.412) for diabetes and 1.85 (95% CI: 1.286∼2.674) for hyperuricemia compared to the normal triglyceride levels with the normal waist (NTNW) group. The area under curve values of the HTGW phenotype for diagnosing metabolic syndrome were 0.849 for all subjects, 0.858 for men, and 0.890 for women. In conclusion, the HTGW phenotype is closely related to metabolic abnormalities and is a useful indicator for monitoring adult hypertensive patients with metabolic syndrome.
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