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한국 성인에서 고요산혈증 위험을 예측하기 위한 중성지방-혈당 지수의 유용성

Usefulness of Triglyceride and Glucose Index to Predict the Risk of Hyperuricemia in Korean Adults

김은재|신경아
한국융합학회 (Korea Convergence Society)|2020.12|한국융합학회논문지 (Journal of the Korea Convergence Society)|제11권 제12호|pp. 283-290|DOI https://doi.org/10.15207/JKCS.2020.11.12.283

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키워드

인슐린저항성Uric acid이상지질혈증DyslipidemiaInsulin resistanceHyperuricemia요산고요산혈증중성지방-혈당 지수Triglyceride and glucose index
주제분류학제간연구

초록

본 연구는 한국 성인을 대상으로 고요산혈증 위험을 예측하기 위한 중성지방-혈당 지수(triglyceride and glucose index, TyG index)의 유용성을 평가하였다. 서울지역 종합병원에서 2017년부터 2019년까지 건강진단을 실시한 20세 이상 남성 14,266명, 여성 9,033명을 대상으로 하였다. TyG 지수에 따른 고요산혈증 발생 위험도는 로지스틱 회귀분석을 실시하였으며, TyG 지수의 고요산혈증 위험 예측능력을 확인하기 위해 ROC 곡선을 구하였다. 고요산혈증을 예측하기 위한 TyG 지수의 정확도는 0.68이며, 남성 0.61, 여성 0.67이었다(각각 p<0.001). TyG 지수의 고요산혈증 발생 위험은 1사분위수보다 4사분위수에서 1.69배 높았으며, 남성은 2.03배, 여성은 2.07배 높았다(각각 p<0.05). 따라서 TyG 지수는 고요산혈증의 선별검사로서 진단적 유용성은 높지 않았으나, TyG 지수와 고요산혈증간에는 관련이 있었다.

Abstract

The purpose of this study was to evaluate the usefulness of the triglyceride and glucose(TyG) index to predict the risk of hyperuricemia in Korean adults. This study included 14,266 men and 9,033 women over 20 years old who underwent health screenings from 2017 to 2019 at a general hospital in Seoul. To confirm the risk of hyperuricemia and predictive ability of the TyG index, logistic regression analysis and ROC curves were obtained. The accuracy of the TyG index for predicting hyperuricemia was 0.68, 0.61 for men and 0.67 for women(respectively p<0.001). The risk of hyperuricemia in the TyG index was 1.69 times higher in the fourth quartile than in the first quartile, 2.03 times higher in men and 2.07 times higher in women(respectively p<0.05). Thus the TyG index was not of high diagnostic usefulness as a screening test for hyperuricemia, but it was related to the TyG index and hyperuricemia.

참고문헌 (36)

  1. Eswar Krishnan, "Interaction of Inflammation, Hyperuricemia, and the Prevalence of Hypertension Among Adults Free of Metabolic Syndrome: NHANES 2009–2010", Journal of the American Heart Association, 3(2) (2014), Ovid Technologies (Wolters Kluwer Health)[DOI]
  2. S. Kodama, "Association Between Serum Uric Acid and Development of Type 2 Diabetes", Diabetes Care, 32(9), pp.1737~1742 (2009), American Diabetes Association[DOI]
  3. Francesca Cortese, "Uric acid: from a biological advantage to a potential danger. A focus on cardiovascular effects", Vascular Pharmacology, 120, pp.106565~ (2019), Elsevier BV[DOI]
  4. Eswar Krishnan, "Hyperuricemia and Incidence of Hypertension Among Men Without Metabolic Syndrome", Hypertension, 49(2), pp.298~303 (2007), Ovid Technologies (Wolters Kluwer Health)[DOI]
  5. Davide Grassi, "Chronic Hyperuricemia, Uric Acid Deposit and Cardiovascular Risk", Current Pharmaceutical Design, 19(13), pp.2432~2438 (2013), Bentham Science Publishers Ltd.[DOI]
  6. Uday M. Khosla, "Hyperuricemia induces endothelial dysfunction", Kidney International, 67(5), pp.1739~1742 (2005), Elsevier BV[DOI]
  7. Denis Roy, "Insulin stimulation of glucose uptake in skeletal muscles and adipose tissues in vivo is NO dependent", American Journal of Physiology-Endocrinology and Metabolism, 274(4), pp.E692~E699 (1998), American Physiological Society[DOI]
  8. E Muscelli, "Effect of insulin on renal sodium and uric acid handling in essential hypertension", American Journal of Hypertension, 9(8), pp.746~752 (1996), Oxford University Press (OUP)[DOI]
  9. Daigo Toyoki, "Insulin stimulates uric acid reabsorption via regulating urate transporter 1 and ATP-binding cassette subfamily G member 2", American Journal of Physiology-Renal Physiology, 313(3), pp.F826~F834 (2017), American Physiological Society[DOI]
  10. Mfon Ewang-Emukowhate, "Dyslipidaemia Related to Insulin Resistance and Cardiovascular Disease in South Asian and West African Populations", Current Pharmaceutical Design, 20(40), pp.6270~6275 (2014), Bentham Science Publishers Ltd.[DOI]
  11. Nasser Mikhail, "The metabolic syndrome: Insulin resistance", Current Hypertension Reports, 11(2), pp.156~158 (2009), Springer Science and Business Media LLC[DOI]
  12. Robert H Eckel, "The metabolic syndrome", The Lancet, 365(9468), pp.1415~1428 (2005), Elsevier BV[DOI]
  13. Gisela Unger, "Índice triglicéridos y glucosa: un indicador útil de insulinorresistencia", Endocrinología y Nutrición, 61(10), pp.533~540 (2014), Elsevier BV[DOI]
  14. A. Sánchez-García, "Diagnostic Accuracy of the Triglyceride and Glucose Index for Insulin Resistance : A Systematic Review", International Journal of Endocrinology, 2020, pp.4678526~ (2020)[DOI]
  15. Laura Sánchez-Íñigo, "The TyG index may predict the development of cardiovascular events", European Journal of Clinical Investigation, 46(2), pp.189~197 (2016), Wiley[DOI]
  16. David Navarro-González, "Triglyceride–glucose index (TyG index) in comparison with fasting plasma glucose improved diabetes prediction in patients with normal fasting glucose: The Vascular-Metabolic CUN cohort", Preventive Medicine, 86, pp.99~105 (2016), Elsevier BV[DOI]
  17. Rongjiong Zheng, "Triglyceride and glucose (TyG) index as a predictor of incident hypertension: a 9-year longitudinal population-based study", Lipids in Health and Disease, 16(1) (2017), Springer Science and Business Media LLC[DOI]
  18. Markku Laakso, "Insulin resistance and hyperglycaemia in cardiovascular disease development", Nature Reviews Endocrinology, 10(5), pp.293~302 (2014), Springer Science and Business Media LLC[DOI]
  19. Pooneh Angoorani, "Validity of triglyceride–glucose index as an indicator for metabolic syndrome in children and adolescents: the CASPIAN-V study", Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity, 23(6), pp.877~883 (2018), Springer Science and Business Media LLC[DOI]
  20. Shi-Wei Yang, "The Impact of Hypoglycemia on the Cardiovascular System", Angiology, 67(9), pp.802~809 (2016), SAGE Publications[DOI]
  21. J.-P. Bastard, "Evaluation of two new surrogate indices including parameters not using insulin to assess insulin sensitivity", resistance in non-diabetic postmenopausal women: A MONET group study, 2012, pp.38(3), 258~263[DOI]
  22. Wenrui Shi, "Usefulness of Triglyceride-glucose Index for estimating Hyperuricemia risk: Insights from a general Population", Postgraduate Medicine, 131(5), pp.348~356 (2019), Informa UK Limited[DOI]
  23. Q. Gu, "Associations of triglyceride-glucose index and its derivatives with hyperuricemia risk : A Cohort study in Chinese general population", International Journal of Endocrinology, 2020, pp.3214716~ (2020)[DOI]
  24. 변준석, "고요산혈증과 Triglyceride Glucose Index의 연관성: 국민건강영양조사(2016년)", Korean Journal of Family Practice, 9(3), pp.266~271 (2019), 대한가정의학회[DOI]
  25. Report of a WHO consultation on obesity: Preventing and managing, the global epidemic, "World Health Organization", ~ (1999)
  26. Lili You, "Prevalence of Hyperuricemia and the Relationship between Serum Uric Acid and Metabolic Syndrome in the Asian Mongolian Area", Journal of Atherosclerosis and Thrombosis, 21(4), pp.355~365 (2014), Japan Atherosclerosis Society[DOI]
  27. D. R. Matthews, "Homeostasis model assessment: insulin resistance and ?-cell function from fasting plasma glucose and insulin concentrations in man", Diabetologia, 28(7), pp.412~419 (1985), Springer Science and Business Media LLC[DOI]
  28. Luis E. Simental-Mendía, "The Product of Fasting Glucose and Triglycerides As Surrogate for Identifying Insulin Resistance in Apparently Healthy Subjects", Metabolic Syndrome and Related Disorders, 6(4), pp.299~304 (2008), Mary Ann Liebert Inc[DOI]
  29. Thomas Bardin, "Impact of comorbidities on gout and hyperuricaemia: an update on prevalence and treatment options", BMC Medicine, 15(1) (2017), Springer Science and Business Media LLC[DOI]
  30. Claudio Borghi, "Serum uric acid and the risk of cardiovascular and renal disease", Journal of Hypertension, 33(9), pp.1729~1741 (2015), Ovid Technologies (Wolters Kluwer Health)[DOI]
  31. Yili Xu, "Hyperuricemia as an Independent Predictor of Vascular Complications and Mortality in Type 2 Diabetes Patients: A Meta-Analysis", PLoS ONE, 8(10), pp.e78206~ (2013), Public Library of Science (PLoS)[DOI]
  32. Yuzhang Zhu, "High uric acid directly inhibits insulin signalling and induces insulin resistance", Biochemical and Biophysical Research Communications, 447(4), pp.707~714 (2014), Elsevier BV[DOI]
  33. Sangsang Li, "The role of the triglyceride (triacylglycerol) glucose index in the development of cardiovascular events: a retrospective cohort analysis", Scientific Reports, 9(1) (2019), Springer Science and Business Media LLC[DOI]
  34. Jing-Lu Jin, "Triglyceride glucose index for predicting cardiovascular outcomes in patients with coronary artery disease", Journal of Thoracic Disease, 10(11), pp.6137~6146 (2018), AME Publishing Company[DOI]
  35. Kerry L. Donnelly, "Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease", Journal of Clinical Investigation, 115(5), pp.1343~1351 (2005), American Society for Clinical Investigation[DOI]
  36. G. M. Reaven, "Role of Insulin Resistance in Human Disease", Diabetes, 37(12), pp.1595~1607 (1988), American Diabetes Association[DOI]

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