Citrus junos fractions Decrease Alcohol-induced Liver Damage and Influence Lipid Metabolism in Alcohol-fed Rats
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Abstract
- The effect of treatment with Citrus junos fractions (citron 3W, citron 3H,citron 4W and citron 4H) upon rat hepatocytes exposed to alcohol was investigated. Wecompared the serum biochemistry of rats administered both alcohol and Citrus junosfractions to control rats treated with alcohol alone. The effects of Alanine amino trans-ferase(ALT) were significantly lower in the citron 3H extract group compared with thenegative control group (p 0.05) and other experimental groups were not significantlylow but a little low compared to negative control group. The levels of triglyceride (TG)were significantly low in all experimental groups compared with negative controlgroup. Especially triglyceride level of citron 3H was lowest near to normal controlgroup. The concentration of total cholesterol was significantly high in negative groupscompared with normal control group but in all experimental groups, the concentrationof total cholesterol was similar to that of negative control group. Total cholesterol ofthe citron 4W group was somewhat low compared with negative control group. In con-mental groups compared with the negative control (p 0.05) group. These data suggestthat Citrus junos fractions may represents an excellent candidate for protection of rathepatocytes from alcohol-mediated damage.
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