Study on the Anti-Hyperlipidemia and Liver Cell Protection of Korean Medicinal Herb Complex of Alcohol Fed Rat
2
조회
0
다운로드
0
인용
0
참고문헌
초록
Abstract
This study sought to investigate the ameliorating effects of a Korean medicinal herb (KMH) complex on the impacts of alcohol consumption in rat hepatocytes and in reducing the total cholesterol levels and the total lipid levels in the serum. We compared the body weight gain and ratio of the liver, the kidney to body weight, and also the serum biochemistry of the rats administered with both the alcohol and the KMH complex to the control rats treated with alcohol alone. The clinically important enzyme markers (Aspartate Aminotransferase, AST, and Alanine Aminotransferase, ALT) of rats, administered with both the alcohol and the KMH complex treatments, were compared with those in the control group. The treatment regimen (KMH complex) significantly reduced the serum AST and ALT levels, indicating the hepato-protective effects of the KMH complex. Furthermore, total cholesterol and total lipid levels were significantly reduced. These results indicate that the KMH complex may positively mediate the effects of alcohol on hepatocytes and the general liver functions.
참고문헌 (18)
- Baraona E, "Effects of chronic ethanolfeeding on serum lipoprotein metabolism in the rat", pp.769~788 (1970)
- Castelli WP, "SerumLipids and risk of coronary artery disease", pp.7~10 (1990)
- Diehl AM, "Effects of alcohol on liver regeneration", pp.279~283 (1993)
- Glueck CJ, "Effectsof alcohol ingestion on lipids and lipoproteins in normalmen", pp.2287~2293 (1980)
- KA Sobocinski, "nutrient intake and relativebody weight among U", pp.289~595 (1985)
- Huh Joon, "Young in Bon-Dong Eu Bo Gam" (1981), Han SungBook Press
- M Ulmer, "Inf luence of chronic ethanol intake on obesity liversteatosis and hyperlipidaemia in the Zucker fa", fa rat, 1985, 5~13
- Kien CL, "Manifestations of chronicselenium deficiency in a child receiving total parenteralnutrition", pp.319~328 (1983)
- Kovanen PT, "Regulation of the Low-densityLipoproteinB", E) Receptor., 1999, pp.5, 165~185
- Lieber C S, "Medical disorders of alcoholism", 333, pp.1058~1065 (1995)
- Lieber CS, "Alcoholic liver injurypathogenesis andtherapy in 2001", 49:, pp.738~752 (2001)
- Maher JJ, "Exploring alcohol’s effects on liver function", 21, pp.5~12 (1997)
- Murray CJL, "The global burden of disease", “The global burden ofdisease”
- Park KJ, "protects liver cell damage induced by alcohol", 25, pp.1451~1455 (2002)
- Piola RC, "Energy wastage in rats givendrugs that induce microsomal enzymes", pp.~1548 (1975)
- Potter SM, "Overview of proposed mechanisms for thehypocholesterolemic effect of soy", 123, pp.606~611 (1995)
- Thompson JN, "Impaired lipid andvitamin E absorption related to atrophy of the pancreasin selenium-deficient chicks", pp.797~809 (1970)
- Tsukamoto H, "Ethanol-induced liver fibrosis in rats fed high fat diet", pp.814~6 822 (1986)