Differential Functions of Caffeine and Ascorbic acid in γ-Irradiated Male Mice
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Abstract
Radioprotection is of practical importance for the normal tissues of tumor patientssubject to radiotherapy, people with planned or accidental exposure to radiation, and the publicand radiation workers. Since oxygen enhances radiationinduced biological damage, antioxi-dants should be related with the function as a radioprotectors. Ascorbic acid or caffeine is anThe present study investigates functional radioprotection of caffeine and ascorbic acid againstgamma radiation in irradiated C57BL/6N mice. Eightweek old male C57BL/6N mice wereirradiated with 6.5Gy. A caffeine treated group was administered with 80mg kg1 body weight byintraperitoneal injection, a single treatment 1hr before irradiation. Ascorbic acid was administer-ed 330 mg L1 in drinking water through all the experimental period. According to timeafter wholebody gamma irradiation. The caffeine treated group showed lower decrement ofbody and organ weights than the other experimental groups. The qualitative analysis of circulat-ing testosterone in serum was performed by means of radioimmunoassay(RIA). The normal levelof circulating testosterone was maintained by the treatment of caffeine and ascorbic acid. Thechange of weight of body and organ and the appearance of seminiferous tubules were improvedby an effect of caffeine or ascorbic acid against irradiation. Taken together, caffeine and ascorbicprotector.
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