감마선 전신 조사와 치커리 가공물 식이가 Streptozotocin 유발 당뇨쥐의 산화적 손상과 지질대사에 미치는 영향

Abstract

- The increased occurrence of hyperglycemia and oxidative stress in streptozotocin(STZ) induced type I diabetes has been implicated in the etiology and pathology of diseasecomplication. STZ has known to be genotoxic in a variety of assays including tests for microbialcondition, resulting in severe metabolic imbalances and non-physiologic changes in many tissues.We examined the effect of gamma radiation and KWNP on preventing the development of insulindependent diabetes mellitus using streptozotocin-induced Fisher 344 diabetic rats. Thehematological values (red blood cell and white blood cell), serum biochemical constituents--were checked and theorgans (testis, spleen and kidney) were weighed. The gonad indices of the STZ treated groupswere much lower than the value of the control group. But the gonad indices of the KWNP treatedgroups were higher than those of the treated groups. The ratio of the weight of kidney to the bodydiabetic group treated with KWNP after irradiation (F group) was lower than the other STZtreated groups. The white blood cell and ALP values of the F group were lower than the otherSTZ groups, as well. The cholesterol and triglyceride values of all the KWNP treated groups weresignificantly lower than the other groups. A significant increase (about 10 times) of insulin wasirradiated and STZ treated groups. The quantity of apoptotic cells in seminiferous tubule of testisconfirmed a serious damage as assessed in the STZ treated groups. These experimental resultshave revealed that treatment of the products of KWNP after irradiation has the antidiabeticeffect in the STZ-induced diabetic rats. But the F group showed higher recuperative power. Theserecovering effect in the STZ-induced diabetic rats.