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The Effects of Hominis Placenta Hydrate (HPH) on the Bone Marrow Failure Induced by 5-Fluorouracil

CHOI Chang Woo|SHIN Jang Woo|CHO Jung Hyo|SON Chang Gue|Lee Yong Yeon|LEE Yeon Weol|YOO Hwa Seung|LEE Nam Heon|Yun Dam Hee|CHO Chong Kwan
대한한방내과학회 (The Society Of Korean Oriental Internal Medicine)|2006.06|대한한방내과학회지 (The Journal of Korean Oriental Internal Medicine)|제27권 제2호|pp. 327-335

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Abstract

Aim: To examine the efficacy of Hominis Placenta Hydrate (HPH) on the hemopoiesis in a myelosuppression model system. Methods: Mice were injected with 5-Fluorouracil (5-FU) intraperitoneally and were administered with 200 mg/kg and 1000 mg/kg of HPH. Peripheral blood was analyzed at 5, 9, and 13 days. Histopathologic examination of bone marrow was performed at 5 days after 5-FU injection. The expression of cytokine involved in hemopoiesis was examined by using ELISA kit. Results: The hematology data demonstrated that the treatment of all the agents augmented monocytes and leucocytes counts in the peripheral blood WBC and platelet in HPH treated group were significant increased compared with control group. Also, cell numbers of RBC and Hb were restored. In HPH treated group, expression of IL-3, GM-CSF was significant increased But not TPO. Conclusions: Based on the above results, it is suggested that Hominis Placenta Hydrate is an effective remedy for the bone marrow failure and myelosuppression occurring during chemotherapy

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