Limitation of Regular Autosomal STR Testing for Paternity within an Isolated Population
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In order to determine paternity by genetic testing, the Paternity Index (PI) and probabilityof paternity are calculated using likelihood ratio method. However, when it isnecessary, additional testing can be performed to validate the genetic relationship. This research demonstrates autosomal short tandem repeat (STR) results of JejuIsland population in order to determine genetic relationship. Two notable casesshowed that despite the acceptable PI value obtained from STR testing, average of12 mismatches were found in total of 169 autosomal single nucleotide polymorphismtyping. Such cases imply that cautious statistical approach is necessary when determininggenetic relationship, especially within an isolated population group. Moreover,this would suggest that a further research and investigation are needed in order tounderstand the population structure of Korea.
Abstract
In order to determine paternity by genetic testing, the Paternity Index (PI) and probabilityof paternity are calculated using likelihood ratio method. However, when it isnecessary, additional testing can be performed to validate the genetic relationship. This research demonstrates autosomal short tandem repeat (STR) results of JejuIsland population in order to determine genetic relationship. Two notable casesshowed that despite the acceptable PI value obtained from STR testing, average of12 mismatches were found in total of 169 autosomal single nucleotide polymorphismtyping. Such cases imply that cautious statistical approach is necessary when determininggenetic relationship, especially within an isolated population group. Moreover,this would suggest that a further research and investigation are needed in order tounderstand the population structure of Korea.
참고문헌 (10)
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