STR 마커를 이용한 한국인에서의 혈연관계 판정기준 분석
Statistical Evaluation of Common Relationships Using STR Markers in Korean Population
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참고문헌
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초록
본 연구는 최근에 가장 많이 사용되고 있는 22개 STR 마커를 이용하여 혈연관계의 식별을 위해 활용될 수 있는 정량적 판정기준 개발을 목적으로 혈연관계에 있는 실제 한국인 가계 자료(735쌍의한 부모-자식 쌍, 444쌍의 형제관계 쌍, 696쌍의 삼촌-조카 쌍, 343쌍의 사촌관계 쌍)를 이용하여 통계 분석을 실시하였다. 또한, 혈연관계 판정을 위한 평가기준으로 우도비(likelihood ratio)의 절단값(cut-off value)과 최대값을 제시하였다.
Abstract
In this study, we propose the discrimination rule for familial relationships in Korean population by analyzing 22 STR loci data obtained from 735 pairs of parent-child, 444 pairs of full sibling, 696 pairs of uncle-nephew, and 343 pairs of cousin. We describe how to evaluate and determine the various relationships by comparing related pairs with unrelated pairs. Also we present the cut-off value and maximum value of a likelihood ratio as a determination rule.
참고문헌 (23)
- M Kayser, "Improving human forensics through advances in genetics, genomics and molecular biology", Nat Rev Genet, 12, pp.179~192 (2011)
- JM Butler, "Biology and genetics of new autosomal STR loci useful for forensic DNA analysis", Forensic Sci Rev, 24, pp.15~26 (2012)
- JA Thomson, "Analysis of disputed single-parent", child and sibling relationship using 16 STR loci, 2001, pp.115, 128~134
- FR Bieber, "Human genetics. Finding criminals through DNA of their relatives", Science, 312, pp.1315~1316 (2006)
- R Gaytmenn, "Determination of the sensitivity and specificity of sibship calculations using AmpF", STR Profiler Plus, 2002, pp.116, 161~164
- B Budowle, "CODIS STR loci data from 41 sample populations", J Forensic Sci, 46, pp.453~489 (2001)
- 이재원, "친자확인을 위한 유전자검사법의 고찰", 法曹, 512, pp.134~154 (1999)
- JM Butler, "Fundamentals of Forensic DNA Typing" (2009), ELSEVIER
- PM Schneider, "Scientific standards for studies in forensic genetics", Forensic Sci Int, 165, pp.238~243 (2007)
- 이재원, "Statistical Evaluation of Sibling Relationship", Communications for Statistical Applications and Methods, 14(3), pp.541~549 (2007), 한국통계학회
- 황정희, "Population Genetic Data and Concordance Study for the PowerPlex ESI17 System and The AmpF", STR IdentifilerTM Kit in Koreans, 2013, pp.7(4), 265~271[DOI]
- B Budowle, "Population genetic analyses of the NGM STR loci", Int J Legal Med, 125, pp.101~109 (2011)
- P Gill, "The evolution of DNA databases recommendations for new European STR loci", Forensic Sci Int, 156, pp.242~244 (2006)
- 양인석, "상염색체 STR 유전자형 시뮬레이션을 이용한 한국인에서의혈연지수 분포 분석", 대한법의학회지, 37(2), pp.57~65 (2013), 대한법의학회[DOI]
- JH Park, "Genetic variation of 23autosomal STR loci in Korean population", Forensic Sci Int :Genetics, 7, pp.76~77 (2013)
- IW Evett, "Interpreting DNA evidence:Statistical genetics for forensic scientists" (1998), Sinauer Associates, Inc
- BS Weir, "Genetic relatedness analysis : modern data and new challenges", Genetics, 7, pp.771~780 (2006)
- KJD Balloch, "Reporting paternity testing results when 2exclusions are encountered", Forensic Sci Int : Genetics Supplement Series, 1, pp.492~493 (2008)
- P Kersbergen, "False positive or true paternity: Investigating one or two STR mismatches by detailed SNP analyses", Forensic Sci Int :Genetics Supplement Series, 1, pp.518~519 (2008)
- S Akhteruzzamana, "False paternity with one or two mismatches using commercial STR kits", Aust J Forensic Sci, 44(3), pp.253~259 (2012)
- 이효정, "Lineage Marker를 이용한 개인식별에서의 통계적 방법", 대한법의학회지, 38(2), pp.39~47 (2014), 대한법의학회
- S Cowen, "A likelihood ratio approach to familial searching of large DNA databases", Forensic Sci Int : Genetics, 1, pp.643~645 (2008)
- J Ge, "Kinship index variations among populations and thresholds for familial searching", PLoS One, 7, pp.e374741~e374748 (2012)