Null and Duplicated Alleles of 17 Y-STR Haplotypes in Koreans and Considerations for Forensic Application
2
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
The analysis of Y chromosome polymorphisms has become common place for the identification of male component in forensic cases. In male/female mixtures of many rape cases, Y-STRs are also very useful for the determination of contributors’ number. During the analyses of 17 Y-STR haplotypes for forensic applications using the AmpFlSTR YfilerTM system, a number of null and duplicated alleles (40 out of 2144subjects) were discovered. Interestingly, two haplotypes should focus the attention on forensic interpretation of Y-STR haplotype profiles, because multiple mutational events at various loci can be interpreted as a wrong mixed or allele drop-out profile.
Abstract
The analysis of Y chromosome polymorphisms has become common place for the identification of male component in forensic cases. In male/female mixtures of many rape cases, Y-STRs are also very useful for the determination of contributors’ number. During the analyses of 17 Y-STR haplotypes for forensic applications using the AmpFlSTR YfilerTM system, a number of null and duplicated alleles (40 out of 2144subjects) were discovered. Interestingly, two haplotypes should focus the attention on forensic interpretation of Y-STR haplotype profiles, because multiple mutational events at various loci can be interpreted as a wrong mixed or allele drop-out profile.
참고문헌 (18)
- Prinz M, "Multiplexing of Y chromosome specific STRs and performance for mixed samples", Forensic Sci Int, 85, pp.209~218 (1997)
- Jobling MA, "The Y chromosome in forensic analysis and paternity testing", Int J Legal Med, 110, pp.118~124 (1997)
- Gill P, "DNA Commission of the International Society of Forensic Genetics: recommendations on forensic analysis using Y-chromosome STRs", Forensic Sci Int, 124, pp.5~10 (2001)
- Butler JM, "Recent developments in Y-short tandem repeat and Y-single nucleotide polymorphism analysis", Forensic Sci Rev, 15, pp.91~111 (2003)
- Lessig R, "Forensic applications of Y-STRs", Forensic Sci Rev, 5, pp.181~188 (2003)
- Ballard DJ, "A study of mutation rates and the characterisation of intermediate, null and duplicated alleles for 13 Y chromosome STRs", Forensic Sci Int, 155, pp.65~70 (2005)
- Diederiche M, "A case of double alleles at three Y-STR loci: forensic implications", Int J Legal Med, 119, pp.223~225 (2005)
- Roewer L, "Y-chromosomal STR haplotypes in Kalmyk population samples", Forensic Sci Int, 173, pp.204~209 (2007)
- Capelli C, "Phylogenetic evidence for multiple independent duplication events at the DYS19 locus", Forensic Sci Int: Genet, 1, pp.287~290 (2007)
- Park MJ, "Charaterization of dele-tions in the DYS385 flanking region and null alleles associated with AZFc microdeletions in Koreans", J Forensic Sci, 53, pp.331~334 (2008)
- Budowle B, "Null allele sequence structure at the DYS448 locus and implications for profile interpretation", Int J Legal Med, 122, pp.421~427 (2008)
- Seong KM, "Population genetic polymorphisms of 17 Y-chromosomal loci in South Koreans", Forensic Sci Int: Genet 2010, ~ (2010)
- Mulero JJ, "Development and validation of the AmpFlSTR¢ÁYfilerTM PCR amplification kit: A male specific, single amplification 17 Y-STR multiplex system", J Forensic Sci, 51, pp.64~75 (2006)
- Butler JM, "Chromosomal duplications along the Y-chromosome and their potential impact on Y-STR interpretation", J Forensic Sci, 50, pp.853~859 (2005)
- Bosch E, "Duplication of the AZFa region of the human Y chromosome are mediated by homologous recombination between HERVs and compatible with male fertility", Hum Mol Genet, 12, pp.341~347 (2003)
- Butler JM, "A novel multiplex for simultaneous amplification of 20 Y chromosome STR markers", Forensic Sci Int, 129, pp.10~24 (2002)
- Butler JM, "Duplication of DYS19 flanking regions in other parts of the Y chromosome", Int J Legal Med, 118, pp.178~183 (2004)
- "Reference tables to: Evaluation of Y-chromosomal STRs: a multicenter study (Kayser et al.) and Chromosome Y microsatellites: population genetic and evolutionary aspects (de Knijff et al.)", Int J Legal Med, 110, pp.141~149 (1997)