멀티라멜라 니오좀을 이용한 레틴알의 안정화 연구
The Stabilization of Retinal Using Multi-lamellar Niosome
3
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Niosomes are double membrane vesicles made using nonionic surfactants, and both hydrophilic and hydrophobic substances can be encapsulated. Skin Lipid Matrix (SLM) is composed of phosphatidylcholine and forms a multi-lamellar structure similar to the lipid layer of the skin. The multi-lamellar retinal niosome included retinal was formed by using niosome and SLM. The retinal is one of the unstable materials in the external environment. The particle size of multi-lamellar retinal niosome is about 300 nm, and the zeta potential was over -40 mV. Compared to general creams containing retinal, the multi-lamellar retinal niosome cream showed higher permeability and stability. This study is expected to be widely used in the field of cosmetics such as stabilization and delivery system of destabilizing materials.
Abstract
Niosomes are double membrane vesicles made using nonionic surfactants, and both hydrophilic and hydrophobic substances can be encapsulated. Skin Lipid Matrix (SLM) is composed of phosphatidylcholine and forms a multi-lamellar structure similar to the lipid layer of the skin. The multi-lamellar retinal niosome included retinal was formed by using niosome and SLM. The retinal is one of the unstable materials in the external environment. The particle size of multi-lamellar retinal niosome is about 300 nm, and the zeta potential was over -40 mV. Compared to general creams containing retinal, the multi-lamellar retinal niosome cream showed higher permeability and stability. This study is expected to be widely used in the field of cosmetics such as stabilization and delivery system of destabilizing materials.
참고문헌 (9)
- A. Sankhyan, "Recent Tends in Niosome as Vesicular Drug Delivery System", J. Appl. Pharm. Sci, 02(06), pp.20~32 (2012)
- N. K. Dahiya, "Preparation and characterization techniques in niosomal vesicular systems- A review", J. Pharm. Biomed. Sci., 5, pp.1~8 (2011)
- I. F. Uchegbu, "Non-ionic surfactant vesicle(niosomes) : physical and pharmaceutical chemistry", Adv. Colloids and Interface Sci, 58, pp.1~55 (1995)
- J. W. Fluhr, , Dermatology, 199, pp.57~60 (1999)
- O. Sorg, "The Potential Depigmentating Activity of Retinaldehyde", Dermatology, 227, pp.231~237 (2013)
- O. Sorg, "Topical Retinoids in Skin Ageing: A Focused Update with Reference to Sun-Induced Epidermal Vitamin A Deficiency", Dermatology, pp.1~12 (2014)
- P. Creidi, "Profilometric evaluation of photodamage after topical retinaldehyde and retinoic acid treatment", J. Amer. Acad. Dermatol, 39, pp.960~965 (1998)
- R. Rajera, "Niosomes : a controlled and novel drug delivery system", Biol. Pharm. Bull, 34(7), pp.945~953 (2011)
- S. Mordon, "Ultrasound imaging demonstration of the improvement of non-ablative laser remodeling by concomitant daily topical application of 0.05% retinalaldehyde", J. Cosmet. Laser Ther., 6, pp.5~9 (2004)