다양한 계면활성제에 따른 니오좀의 형성 안정화에 한 연구
The Formation and Stabilization of Niosome with Various Surfactants
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The niosome can encapsulate both hydrophilic and lipophilic materials and can selectively extend the release of the encapsulated drug. The particle size, zeta potential, stability, and skin permeation effect were analyzed for niosome synthesized with various types of surfactants and microfludizer. The particle size of the synthesized niosome was 140-250 nm and the zeta potential, the surface potential of the particles, was in the range of -40 to -60 mV. The structure of niosome formed multi-lamellar structures well and We could find the most stable niosome through stability analysis using the turbiscan. When the skin permeation evaluation was conducted with retinol cream, the absorption of retinol showed the best effect in niosome cream. Based on these findings, it is expected that niosome will play a role as a stable nano-carrier in drug delivery systems and cosmetics.
Abstract
The niosome can encapsulate both hydrophilic and lipophilic materials and can selectively extend the release of the encapsulated drug. The particle size, zeta potential, stability, and skin permeation effect were analyzed for niosome synthesized with various types of surfactants and microfludizer. The particle size of the synthesized niosome was 140-250 nm and the zeta potential, the surface potential of the particles, was in the range of -40 to -60 mV. The structure of niosome formed multi-lamellar structures well and We could find the most stable niosome through stability analysis using the turbiscan. When the skin permeation evaluation was conducted with retinol cream, the absorption of retinol showed the best effect in niosome cream. Based on these findings, it is expected that niosome will play a role as a stable nano-carrier in drug delivery systems and cosmetics.
참고문헌 (11)
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