유전영동을 이용한 미세유체채널 내부의 입자 손실 저감 기술
Particle Loss Reduction Technique Using Dielectrophoresis in Microfluidic Channel
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This paper demonstrates a novel electrodynamic technique to remove particles from the wall of microchannels. Dielectrohporesis(DEP) is generated by applying alternating electric potentials to the interdigitated electrodes integrated at the bottom of the micro-channel. The proposed technique is applied to a general microfluidic channel as a feasibility test.To examine the wall loss reduction efficiency, 10 μm diameter Polystyrene latexes(PSL) were supplied to the inlet of the device. Then, the concentration of collected particles through devices was measured. In the experiment for 10 μm diameter PSL particles, the concentration of the injected particles was 174.25×10^4particles/ml. However, the concentration of collected particles at the outlet was 52.25×10^4 particles/ml. Only 30 % of particles had arrived at the outlet and 70 % of particles had adhered to the wall of the microfluidic channel. By applying alternating electric potentials from 0 to 20 V_(pp) at 3 MHz, the concentration of injected particles was 135.00×10^4 particles/ml, the concentration of collected particles was increased as 105.25×10^4 particles/ml at 20 V_(pp) at the outlet. When the electric potential was 20 Vpp, the particle loss was decreased by 39 % (initial loss: 70 %, loss at 20 V_(pp): 31 %) with 10 μm particle. The particle loss was decreased along to the incensement of electric potentials and the enlargement of the diameter of particles. According to these measured results, it was confirmed that the proposal of using DEP technique could be a good candidate for particle loss reduction in micro-particle processing chip application. Moreover, it is expected that the proposed technique could enhance performance of microfluidic and biochip devices.
Abstract
This paper demonstrates a novel electrodynamic technique to remove particles from the wall of microchannels. Dielectrohporesis(DEP) is generated by applying alternating electric potentials to the interdigitated electrodes integrated at the bottom of the micro-channel. The proposed technique is applied to a general microfluidic channel as a feasibility test.To examine the wall loss reduction efficiency, 10 μm diameter Polystyrene latexes(PSL) were supplied to the inlet of the device. Then, the concentration of collected particles through devices was measured. In the experiment for 10 μm diameter PSL particles, the concentration of the injected particles was 174.25×10^4particles/ml. However, the concentration of collected particles at the outlet was 52.25×10^4 particles/ml. Only 30 % of particles had arrived at the outlet and 70 % of particles had adhered to the wall of the microfluidic channel. By applying alternating electric potentials from 0 to 20 V_(pp) at 3 MHz, the concentration of injected particles was 135.00×10^4 particles/ml, the concentration of collected particles was increased as 105.25×10^4 particles/ml at 20 V_(pp) at the outlet. When the electric potential was 20 Vpp, the particle loss was decreased by 39 % (initial loss: 70 %, loss at 20 V_(pp): 31 %) with 10 μm particle. The particle loss was decreased along to the incensement of electric potentials and the enlargement of the diameter of particles. According to these measured results, it was confirmed that the proposal of using DEP technique could be a good candidate for particle loss reduction in micro-particle processing chip application. Moreover, it is expected that the proposed technique could enhance performance of microfluidic and biochip devices.
참고문헌 (19)
- Robert Johann, "A simple mechanism for reliable particle sorting in a microdevice with combined electroosmotic and pressure-driven flow", Electrophoresis, 25, pp.3720~3729 (2004)
- A. D. Goater, "Electrorotation and dielectrophoresis", Parasitology, 117, pp.177~189 (1998)
- P. Gravesen, "Microfluidics-a review", Journal of Micromechanicsand Microengineering, 3, pp.168~182 (1993)
- Chih-Ming Ho, "Micro-electromechanical", systems(MEMS) and fluid flows, 30, pp.579~612 (1998)
- Junya Takagi, "Continuous particle separation in a microchannel having asymmetrically arranged multiple branches", Lab on a Chip, 5, pp.778~784 (2005)
- Hans M. Wyss, "Mechanism for clogging of microchannels", Physical Review E, 74, pp.61~402 (2006)
- M. L. Zoeteweij, "Particle removal in linear shear flow:Model prediction and experimental validation", Journal of Adhesion Science and Technology, 23, pp.899~911 (2009)
- JeromeCardot, "Adhesion and removal of particles from surfacesunder humidity controlled air stream", The Journal ofAdhesion, 75, pp.315~368 (2001)
- G.M. Burdick, "Describing hydrodynamic particle removal fromsurfaces using the particle Reynolds number", Journalof Nanoparticle Research, 3, pp.455~467 (2001)
- A.D. Farmer, "Effect of ultrasound on surface cleaning of silica particles", International Journal of Mineral Processing, 60, pp.101~113 (2000)
- Kaveh Bakhtari, "Experimental and numerical investigation of nanoparticle removal using acoustic streaming and the effect of time", Journal of The Electrochemical Society, 153, pp.846~850 (2006)
- Dongeun Huh, "Garavity-driven microfluidic particle sorting device with hydrodynamic separation amplification", Analytical Chemistry, 79, pp.1369~1376 (2007)
- Hiroaki Masuda, "Powder technology handbook" (2006), CRC Taylor& Francis
- J.Visser, "Particle adhesion and removal:a review", Particulate Science and Technology, 13, pp.139~196 (1995)
- William C. Hinds, "Aerosol Technology ; Properties, Behavior, and Measurement of Airborne Particles", pp.141~149 (1999), John Wiley & Sons
- C. Zhang, "Dielectrophoresis for manipulation of micro", nano particles in microfluidic systems, 2010, pp.396, 401~420
- Michael Pycraft Hughes, "AC electrokinetics:applications for nanotechnology", Nanotechnology, 11, pp.124~132 (2000)
- Thomas B. Jones, "Electromechanics of Particles", pp.34~61 (1995), Cambridge University Press
- Jun Yang, "Cell separation on microfabricated electrodes using dielectrophoretic", gravitational field-flow fractionation, 1999, pp.71, 911~918