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고효율 크기 가변적 입자 분리를 위한 통합 하이브리드 소자

Integrated Hybrid Device for High-Efficiency Size-Tunable Particle Separation

박지온|김태은|박규빈|박채원|강태경|임현정|안준석|이민정|남정훈|오가영|김여진|추승희
대한의용생체공학회 (The Korea Society Of Medical & Biological Engineering)|2022.06|의공학회지 (Journal of biomedical Engineering Research)|제43권 제3호|pp. 170-176

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참고문헌

키워드

SeparationSurface acoustic waveHybrid deviceViscoelastic focusing

초록

Cell separation from a heterogenous mixture sample is an essential process for downstream analysis in biological, chemical, and clinical applications. This study demonstrates an integrated hybrid device of the viscoelastic focusing in a straight rectangular channel and subsequent size-based separation using acoustophoresis to attain high efficiency and separation tunability. For particle pre-alignment in a viscoelastic fluid, the flow rate higher than 10 μl/ min was required. Surface acoustic wave-based lateral migration of particles with different sizes (13 and 27 μm) was examined at various applied voltages and flow rate conditions. Therefore, the flow rate of 100 μl/min and the applied voltage of 20 Vpp can be used for size-based particle separation.

Abstract

Cell separation from a heterogenous mixture sample is an essential process for downstream analysis in biological, chemical, and clinical applications. This study demonstrates an integrated hybrid device of the viscoelastic focusing in a straight rectangular channel and subsequent size-based separation using acoustophoresis to attain high efficiency and separation tunability. For particle pre-alignment in a viscoelastic fluid, the flow rate higher than 10 μl/ min was required. Surface acoustic wave-based lateral migration of particles with different sizes (13 and 27 μm) was examined at various applied voltages and flow rate conditions. Therefore, the flow rate of 100 μl/min and the applied voltage of 20 Vpp can be used for size-based particle separation.

참고문헌 (47)

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