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한약의 장내미생물 조절 효과에 대한 국내외 실험 연구 고찰

A Review of the Experimental Studies on the Modulatory Effect Herbal Medicine on Gut Microbiota

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초록

Objectives: The purpose of this study is to analyze the effect of various herbal medicin on gut microbiota. Methods: Electronic searches were performed using NDSL, OASIS, KISS, KMBASE, K-portal, Pub med, Cochrane, CNKI. Results: we analyzed 25 experimental studies on the effect of herbal medicine on microbiota. Diabetes, obesity, inflammatory bowel disease have been frequently studied in micobiota-related disease. The most common experimental animal model used in the studies C57BL/7 mouse. Among the studies wherein single herbal medication were used, Gynostemma pentaphyllum was most commonly studies, and different herbal medications were used in the studies wherein complex herbal medications were studied. Next generation sequencing was performed using Illumina MiSeq system, and gut microbiota analysis was performed using QIIME and Ribosomal Database Project (RDP). In most studies, the herbal medicines exerted regulatory effects on gut microbiota and improved the symptoms of the experimental groups. Conclusions: This review provides basic data on the correlation between korean medicine and gut microbiota, as well as information for the development of korean medicine.

Abstract

Objectives: The purpose of this study is to analyze the effect of various herbal medicin on gut microbiota. Methods: Electronic searches were performed using NDSL, OASIS, KISS, KMBASE, K-portal, Pub med, Cochrane, CNKI. Results: we analyzed 25 experimental studies on the effect of herbal medicine on microbiota. Diabetes, obesity, inflammatory bowel disease have been frequently studied in micobiota-related disease. The most common experimental animal model used in the studies C57BL/7 mouse. Among the studies wherein single herbal medication were used, Gynostemma pentaphyllum was most commonly studies, and different herbal medications were used in the studies wherein complex herbal medications were studied. Next generation sequencing was performed using Illumina MiSeq system, and gut microbiota analysis was performed using QIIME and Ribosomal Database Project (RDP). In most studies, the herbal medicines exerted regulatory effects on gut microbiota and improved the symptoms of the experimental groups. Conclusions: This review provides basic data on the correlation between korean medicine and gut microbiota, as well as information for the development of korean medicine.

참고문헌 (49)

  1. Clemente JC, "The impact of the gut microbiota on human health: an integrative view", Cell, 148, pp.1258~1270 (2012)
  2. You HJ, "Concepts and strategies of the human intestinal microbiome research", The Korean Journal of Public Health, 52(1), pp.11~19 (2015)
  3. Human microbiome project consortium, "A framework for human microbiome research", Nature, 486, pp.215~221 (2012)
  4. Dominguez-Bello MG, "Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns", Proc Natl Acad Sci USA, 107, pp.11971~11975 (2010)
  5. Schwartz S, "A metagenomic study ofdiet-dependent interaction between gut microbiota and host in infants reveals differences in immune response", Genome Biol, 13, pp.r32~ (2012)
  6. Koenig JE, "Succession of microbial consortia in the developing infant gut microbiome", Proc Natl Acad Sci USA, 108(Suppl 1), pp.4578~4585 (2011)
  7. Lutgendorff F, "The role of microbiota and probiotics in stress-induced gastro-intestinal damage", Curr Mol Med, 8(4), pp.282~298 (2008)
  8. 김민지, "산사의 장내 미생물 조절을 통한 항비만 효과", 한방재활의학과학회지, 29(4), pp.15~27 (2019), 한방재활의학과학회[DOI]
  9. 박정현, "비만에서 장내 미생물 균총의 역할과 발효 한약의 활용", 한방비만학회지, 9(1), pp.1~14 (2009), 한방비만학회
  10. Han L, "Beneficial effects of potentilla discolor bunge water extract on inflammatory cytokines release and gut microbiota in high-fat diet and streptozotocin-induced type 2 diabetic mice", Nutrients, 11(3), pp.670~ (2019)
  11. Cao Y, "Jinqi jiangtang tablet regulates gut microbiota and improve insulin sensitivity in type 2 diabetes mice", J of Diabetes Res, pp.1872134~ (2019)
  12. Chen M, "Huang-lian-jie-du-decoction ameliorates hyperglycemia and insulin resistant in association with gut microbiota modulation", Front Microbiol, 9, pp.2380~ (2018)
  13. Wei X, "Xiexin tang improves the symptom of type 2 diabetic rats by modulation of the gut microbiota", Sci Rep, 8(1), pp.3685~ (2018)
  14. Gao K, "Effects of qijian mixture on type 2 diabetes assessed by metabonomics, gut microbiota and network pharmacology", Pharmacol Res, 130, pp.93~109 (2018)
  15. Gu W, "Water extract from processed polygonum multiflorum modulate gut microbiota and glucose metabolism on insulin resistant rats", BMC Complement Med Ther, 20(1), pp.107~ (2020)
  16. Wu R, "Linggui zhugan formula improves glucose and lipid levels and alters gut microbiota in high-fat diet-induced diabetic mice", Front Physiol, 10, pp.918~ (2019)
  17. Zheng J, "Buzangtongluo decoction improved hindlimb ischemia by activating angiogenesis and regulating gut microbiota in diabetic mice", J Ethnopharmacol, 248, pp.112330~ (2020)
  18. Gong S, "Traditional chinese medicine formula kang shuai lao pian improves obesity, gut gysbiosis, and fecal metabolic disorders in high-fat diet-fed mice", Front Pharmacol, 11, pp.297~ (2020)
  19. Zhang C, "Caulis spatholobi ameliorates obesity through activating brown adipose tissue and modulating the composition of gut microbiota", Int J Mol Sci, 20(20), pp.5150~ (2019)
  20. Chang CJ, "Ganoderma lucidum reduces obesity in mice by modulating the composition of the gut microbiota", Nat Commun, 6, pp.7489~ (2015)
  21. Gu Y, "Characteristic of traditional chinese medicine syndrome elements distribution in patients with overweight and simple obesity and effects of jianpi tiao guan yin on white fat browning and gut microbiota in obese mice", pp.2018
  22. Huang X, "Gypenosides improve the intestinal microbiota of non-alcoholic fatty liver in mice and alleviate its progression", Biomed Pharmacother, 118, pp.109258~ (2019)
  23. Jia N, "Amelioration of hepatic steatosis is associated with modulation of gut microbiota and suppression of hepatic miR-34a in gynostemma pentaphylla (thunb.) makino treated mice", J Nutr Metab (Lond), 15, pp.86~ (2018)
  24. Chen Y, "Wuji wan formula ameliorates diarrhea and disordered colonic motility in post-inflammation irritable bowel syndrome rats by modulating the gut microbiota", Front Microbiol, 8, pp.2307~ (2017)
  25. Li J, "Tong-xie-yao-fang regulates 5-HT level in diarrhea predominant irritable bowel syndrome through gut microbiota modulation", Front Pharmacol, 9, pp.1110~ (2018)
  26. Zhang Z, "Ping weisan alleviates chronic colitis in mice by regulating intestinal microbiota composition", J Ethnopharmacol, 255, pp.112715~ (2020)
  27. Wu ZC, "Sanhuang shu'ai decoction alleviates DSS-induced ulcerative colitis via regulation of gut microbiota, inflammatory mediators and cytokines", Biomed Pharmacother, 125, pp.109934~ (2020)
  28. Shi K, "Deep-fried atractylodis rhizoma protects against spleen deficiency-induced diarrhea through regulating intestinal inflammatory response and gut microbiota", Int J Mol Sci, 21(1), pp.124~ (2019)
  29. Shenghua P, "An integrated fecal microbiome and metabolome in the aged mice reveal anti-aging effects from the intestines and biochemical mechanism of FuFang zhenshu TiaoZhi (FTZ)", Biomed Pharmacother, 121, pp.109421~ (2020)
  30. Zhang F, "Protective effect of Tong-qiao-huo-xue decoction on inflammatory injury caused by intestinal microbial disorders in stroke rats", Biol Pharm Bull, 43(5), pp.788~800 (2020)
  31. Zhang H, "Canmei formula reduces colitis-associated colorectal carcinogenesis in mice by modulating the composition of gut microbiota", Front Oncol, 9, pp.1149~ (2019)
  32. Zhang WJ, "Naoxintong capsule inhibits the development of cardiovascular pathological changes in bama minipig through improving gut microbiota", Front Pharmacol, 10, pp.1128~ (2019)
  33. Qu W, "Impact of traditional chinese medicine treatment on chronic unpredictable mild stress-induced depression-like behaviors and fecal microbiota", Master, pp.2019
  34. The NIH HMP working group, "The NIH human microbiome project", Genome Res, 19(12), pp.2317~2323 (2009)
  35. An X, "The interaction between the gut microbiota and herbal medicines", Biomed Pharmacother, 118, pp.109252~ (2019)
  36. 유동렬, "소아과학 관점에서 바라본 장내 미생물 연구 동향과 향후 방향", 대한한방소아과학회지, 33(1), pp.34~45 (2019), 대한한방소아과학회[DOI]
  37. Kostic AD, "Exploring host-microbiota interactions in animal models and humans", Genes Dev, 27, pp.701~718 (2013)
  38. Korean association for laboratory animal science commission of accreditation committee, "Animal experiment guide", OKVET, 9~46 (2015)
  39. Hebbard L, "Animal models of nonalcoholic fatty liver disease", Nat Rev Gastroenterol Hepatol, 8, pp.35~44 (2010)
  40. Jang BI, "Animal modles of inflammatory bowel disease", Intest Tes, 6(1), pp.8~18 (2008)
  41. Compilation Committee of National Universitiy of Korean Medicine, "Herbology", pp.218~221 (2017), Yeonglimsa
  42. Kim JM, "Identification of anti-inflammatory target genes of rhizoma coptidis extract in lipopolysaccharide-stimulated RAW264.7murine macrophage-like cells", J Ethnopharmacol, 130(2), pp.354~362 (2010)
  43. Kim GM, "Ulmus macrocarpa Hance extract has effects on intestinal microflora of healthy persons", Master, pp.2018
  44. Kim OS, "Introducing EzTaxon-e: a prokaryotic 16S rRNA gene sequence database with phylotypes that represent uncultured species", Int J Syst Evol Microbiol, 62(Pt 3), pp.716~721 (2012)
  45. Caporaso JG, "QIIME allows analysis of high-throughput community sequencingdata", Nat Methods, 7(5), pp.335~336 (2010)
  46. Yilmaz P, "The SILVA and "All-species Living Tree Project (LTP)" taxonomic frameworks", Nucleic Acids Res, (Database issue), pp.D643~D648 (2014)
  47. Cole JR, "Ribosomal database project: data and tools for high throughput rRNA analysis", Nucleic Acids Res, 42(Database issue), pp.D633~D642 (2014)
  48. Federhen, S, "The NCBI taxonomy database", Nucleic Acids Res, 40(Database issue), pp.D136~D143 (2012)
  49. Troy EB, "Beneficial effects of bacteroides fragilis polysaccharides on the immune system", Front Biosci (Landmark Ed), 15, pp.25~34 (2010)

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