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고강도와 중등강도 유산소성 운동이 중년 여성의 혈중 BDNF 농도, 노화 관련 호르몬 및 생활습관병 관련 혈액 변인에 미치는 영향

The effects of regular vigorous- and moderate-intensity aerobic exercise on serum BDNF level, aging- and lifestyle disease-related blood components in middle-aged women

안지영|이진석|고재면
국민체육진흥공단 한국스포츠과학원 (Korea Institute of Sport Science)|2020.03|체육과학연구 (Korean Journal of Sport Science)|제31권 제1호|pp. 11-23|DOI 10.24985/kjss.2020.31.1.11

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참고문헌

키워드

노화관련 호르몬BDNFAerobic exercise유산소성 운동생활습관병 관련 혈액 변인Aging-Related HormoneLifestyle-Related Disease
주제분류체육

초록

[목적] 본 연구는 8주간 고강도와 중등강도 유산소성 운동이 중년 여성의 혈중 BDNF 농도 및 노화 관련 호르몬, 생활습관병 관련 혈액 변인, 그리고 신체구성, 유산소성수행능력에 미치는 영향을 규명하고자 하였다. [방법] 연구대상자는 신체적으로 건강한 50대 여성 총 19명을 대상으로 하였으며, 연구대상자들은 고강도 유산소성 운동 그룹(VIAE, n=10)과 중등강도 유산소성 운동 그룹(MIAE, n=9)으로 무작위 분류하였다. 유산소성 운동은 8주간 주 3회 트레드밀 달리기 형태로 실시하였으며, 운동부하검사를 통해 VO2max를 기준으로 고강도 운동 그룹(VIAE)은 VO2max의 75~80% 강도, 중등강도 운동 그룹(MIAE)은 VO2max의 55~60% 강도에 해당하는 운동 강도 및 운동 시간을 적용하였다. 유산소성 강도에 따른 효과를 규명하기 위하여 사전·사후 연구대상자들의 혈액 샘플을 채취하고 혈중 BDNF 농도 및 노화 관련 호르몬 그리고 생활습관병 관련 혈액을 분석하였으며, 신체구성 및 유산소성 수행능력을 측정하였다. [결과] 첫째, 최대산소섭취량(VO2max)은 VIAE 그룹이 MIAE 그룹보다 사후에 더욱 유의하게 증가하였다(p<.05)(Table 4). 둘째, 신체구성의 경우 체중(kg), BMI, 체지방률(%)이 두 그룹 모두 사전보다 사후에 유의하게 감소하였다(p<.05)(Table 5). 셋째, 혈중 BDNF 농도는 VIAE 그룹이 MIAE 그룹보다 사후에 더욱 유의하게 증가하였다(p<.05). 그리고 혈중 DHEA-s와 IGF-1 농도는 두 그룹 모두 사전보다 사후에 유의하게 증가하였다(p<.05)(Table 6). 넷째, 혈중 FFA, TG 농도는 두 그룹 모두 사전보다 사후에 유의하게 감소하였고(p<.05), HDL-C 농도는 두 그룹 모두 사전보다 사후에 유의하게 증가하였다(p<.05)(Table 7). [결론] 8주간 고강도 유산소성 운동은 중등강도와 비교하여 중년 여성의 최대산소섭취량(VO2max), 혈중 BDNF 농도를 더욱 증가할 뿐만 아니라 노화 관련 호르몬 및 생활습관병 관련 혈액 인자의 긍정적인 변화를 유도할 수 있음을 시사한다.

Abstract

[Purpose] The purpose of this study was to investigate the effects of regular vigorous- and moderate-intensity aerobic exercise on serum brain-derived neurotrophic factor (BDNF) level, aging- and lifestyle disease-related blood components in middle-aged women. [Methods] The participants were recruited from a total of 19 physically healthy people aged 50-59 years, and were randomly divided into vigorous-intensity aerobic exercise (VIAE, n = 10) and moderate-intensity aerobic exercise (MIAE, n = 9) group. The participants were performed vigorous- and moderate-intensity aerobic exercise three times a week for eight weeks, and body composition measurement, graded exercise test, blood collection were performed before and after. [Results] Mean exercise time was significantly longer in the MIAE group than in the VIAE group. The VO2max was significantly higher in the VIAE group than in the MIAE group. Body weight, BMI, and body fat percentage were significantly lower than pre both groups. The BDNF concentration was significantly higher in the VIAE group than in the MIAE group. The dehydroepiandrosterone sulfate (DHEA-s) and insulin-like growth factor-1 (IGF-1) concentration were significantly higher than pre both groups. The free fatty acid and triglyceride concentrations were significantly lower than pre both groups, and HDL-C concentrations were significantly higher than pre both groups. [Conclusion] Vigorous-intensity aerobic exercise not only increases maximal oxygen uptake and blood BDNF level in middle-aged women, but also induces positive changes in aging-related hormones and lifestyle-related blood variables.

참고문헌 (63)

  1. Korea statistics, "Population projection", ~ (2019)
  2. American College of Sports Medicine, "ACSM's guidelines for exercise testing and prescription" (2018), Wolters Kluwer
  3. Aoike, D. T., "Impact of home-based aerobic exercise on the physical capacity of overweight patients with chronic kidney disease", International urology and nephrology, 47(2), pp.359~367 (2015)
  4. Ainsworth, B. E., "Compendium of physical activities: an update of activity codes and MET intensities", Medicine and science in sports and exercise, 32(9;SUPP, pp.1) (2000), S498~S504
  5. Afzalpour, M. E., "Comparing interval and continuous exercise training regimens on neurotrophic factors in rat brain", Physiology & behavior, 147, pp.78~83 (2015)
  6. Aguiar Jr, A. S., "Short bouts of mild-intensity physical exercise improve spatial learning and memory in aging rats: involvement of hippocampal plasticity via AKT, CREB and BDNF signaling", Mechanisms of ageing and development, 132(11-12), pp.560~567 (2011)
  7. Aleman, A., "Insulin-like growth factor-I and cognitive function in healthy older men", The Journal of Clinical Endocrinology &Metabolism, 84(2), pp.471~475 (1999)
  8. Angelucci, F., "The effects of motor rehabilitation training on clinical symptoms and serum BDNF levels in Parkinson’s disease subjects", Canadian Journal of Physiology and Pharmacology, 94(4), pp.455~461 (2016)
  9. Araki, S., "Decreased plasma levels of brain-derived neurotrophic factor and its relationship with obesity and birth weight in obese Japanese children", Obesity Research and Clinical Practice, 8(1), pp.e63~e69 (2014)
  10. Bergeron, J., "Race differences in the response of postheparin plasma lipoprotein lipase and hepatic lipase activities to endurance exercise training in men : results from the HERITAGE Family Study", Atherosclerosis, 159(2), pp.399~406 (2001)
  11. Bernhardt, V., "Aerobic exercise training without weight loss reduces dyspnea on exertion in obese women", Respiratory physiology & neurobiology, 221, pp.64~70 (2016)
  12. Bisdee, J. T., "Metabolic changes during the menstrual cycle", British journal of nutrition, 61(3), pp.641~650 (1989)
  13. Botero, J. P., "Does aerobic exercise intensity affect health‐related parameters in overweight women?", Clinical physiology and functional imaging, 34(2), pp.138~142 (2014)
  14. Carrera-Quintanar, L., "Effect of a 2000-m running test on antioxidant and cytokine response in plasma and circulating cells", Journal of physiology and biochemistry, 73(4), pp.523~530 (2017)
  15. Cayla, J. L., "Erythropoietin induces a shift of muscle phenotype from fast glycolytic to slow oxidative", International journal of sports medicine, 29(06), pp.460~465 (2008)
  16. Colcombe, S. J., "Aerobic fitness reduces brain tissue loss in aging humans", The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 58(2), pp.M176~M180 (2003)
  17. Conraads, V. M., "Aerobic interval training and continuous training equally improve aerobic exercise capacity in patients with coronary artery disease : the SAINTEX-CAD study", International journal of cardiology, 179, pp.203~210 (2015)
  18. Corpas, E., "Human growth hormone and human aging", Endocrine reviews, 14(1), pp.20~39 (1993)
  19. Corripio, R., "Plasma brain-derived neurotrophic factor in prepubertal obese children : results from a 2-year lifestyle intervention programme", Clinical Endocrinology, 77, pp.715~720 (2012)
  20. Cowansage, K. K., "Brain-derived neurotrophic factor : a dynamic gatekeeper of neural plasticity", Current molecular pharmacology, 3(1), pp.12~29 (2010)
  21. Dandanell, S., "Relationship between volition, physical activity and weight loss maintenance : study rationale, design, methods and baseline characteristics", Scandinavian journal of public health, 45(3), pp.299~304 (2017)
  22. Di Blasio, A., "Psychophysical health status of breast cancer survivors and effects of 12 weeks of aerobic training", Complementary therapies in clinical practice, 27, pp.19~26 (2017)
  23. Dimeo, F., "Benefits from aerobic exercise in patients with major depression : a pilot study", British journal of sports medicine, 35(2), pp.114~117 (2001)
  24. Ferris, L. T., "The effect of acute exercise on serum brain-derived neurotrophic factor levels and cognitive function", Medicine and science in sports and exercise, 39(4), pp.728~ (2007)
  25. Franks, D., "Health Fitness Instructor’s Handbook" (1998), Human Kinetics
  26. Gauchard, G. C., "Influence of regular proprioceptive and bioenergetic physical activities on balance control in elderly women", The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 58(9), pp.M846~M850 (2003)
  27. Gordon, D. J., "High-density lipoprotein cholesterol and cardiovascular disease. Four prospective American studies", Circulation, 79(1), pp.8~15 (1989)
  28. Gormley, S. E., "Effect of intensity of aerobic training on V-O2max", Medicine & Science in Sports & Exercise, 40(7), pp.1336~1343 (2008)
  29. Ha, M. S., "Combined exercise is a modality for improving insulin resistance and aging-related hormone biomarkers in elderly Korean women", Experimental Gerontology, 114, pp.13~18 (2018)
  30. Izzicupo, P., "Walking training affects dehydroepiandrosterone sulfate and inflammation independent of changes in spontaneous physical activity", Menopause, 20(4), pp.455~463 (2013)
  31. Jeon, Y. K., "The effect of exercise intensity on brain derived neurotrophic factor and memory in adolescents", Environmental health and preventive medicine, 22(1), pp.27~ (2017)
  32. Jordy, A. B., "Analysis of the liver lipidome reveals insights into the protective effect of exercise on high-fat diet-induced hepatosteatosis in mice", American Journal of Physiology-Endocrinology and Metabolism (2015)
  33. Kannan, U., "Effect of exercise intensity on lipid profile in sedentary obese adults", Journal of clinical and diagnostic research, 8(7), pp.BC08~ (2014)
  34. Kelly, K. R., "Lifestyle-induced decrease in fat mass improves adiponectin secretion in obese adults", Medicine and science in sports and exercise, 46(5), pp.920~926 (2014)
  35. Kennedy, G., "How Does Exercise Reduce the Rate of Age-Associated Cognitive Decline? A Review of Potential Mechanisms", J Alzheimers Dis, 55(1), pp.1~18 (2016)
  36. Khoo, J., "Comparing effects of low-and hihg-volume moderate-intensity exercise on sexual function and testosterone in obese men", The Journal of Sexual Medicine, 10(7), pp.1823~1832 (2013)
  37. Mackay, C. P., "The effect of aerobic exercise on brain-derived neurotrophic factor in people with neurological disorders: a systematic review and meta-analysis", Neural plasticity (2017)
  38. Marandi, S. M., "Effects of intensity of aerobics on body composition and blood lipid profile in obese", overweight females, 2013, pp.4(Suppl 1), S118~
  39. Mezghanni, N., "Effect of exercise training intensity on body composition, lipid profile, and insulin resistance in young obese women", African Journal of Microbiology Research, 6(10), pp.2481~2488 (2012)
  40. McArdle, W. D., "Exercise physiology: nutrition, energy, and human performance" (2010), Lippincott Williams & Wilkins
  41. McCusker, R. H., "Insulin-like growth factor-I enhances the biological activity of brain-derived neurotrophic factor on cerebrocortical neurons", Journal of neuroimmunology, 179(1-2), pp.186~190 (2006)
  42. Matthews, V., "Brain-derived neurotrophic factor is produced by skeletal muscle cells in response to contraction and enhances fat oxidation via activation of AMP-activated protein kinase", Diabetologia, 52(7), pp.1409~1418 (2009)
  43. Narayani, U., "Effect of aerobic training on percentage of body fat, total cholesterol and HDL-C among obese women", World Journal of Sport Sciences, 3(1), pp.33~36 (2010)
  44. Norton, K., "Position statement on physical activity and exercise intensity terminology", Journal of science and medicine in sport, 13(5), pp.496~502 (2010)
  45. Ouerghi, N., "Effects of a high-intensity intermittent training program on aerobic capacity and lipid profile in trained subjects", Journal of sports medicine, 5, pp.243~ (2014)
  46. 박상갑, "복합운동이 비만 중년 남성의 경동맥 최고수축기 혈류속도와 상완동맥 혈류중재 확장반응에 미치는 영향", 한국사회체육학회지, (39), pp.673~682 (2010), 한국사회체육학회
  47. Pedersen, T. R., "Lipoprotein changes and reduction in the incidence of major coronary heart disease events in the Scandinavian Simvastatin Survival Study(4S)", Circulation, 97(15), pp.1453~1460 (1998)
  48. Pesta, D. H., "Resistance training to improve type 2diabetes : working toward a prescription for the future", Nutrition & metabolism, 14(1), pp.24~ (2017)
  49. Ross, R. E., "High-Intensity Aerobic Exercise Acutely Increases Brain-derived Neurotrophic Factor", Medicine and science in sports and exercise, 51(8), pp.1698~1709 (2019)
  50. Rojas Vega, S., "pH buffering does not influence BDNF responses to exercise", International Journal of Sports Medicine, 33(1), pp.8~12 (2012)
  51. Ruscheweyh, R., "Physical activity and memory functions : an interventional study", Neurobiology of aging, 32(7), pp.1304~1319 (2011)
  52. Schmolesky, M. T., "The Effects of Aerobic Exercise Intensity and Duration on Levels of Brain Derived Neurotrophic Factor in Healthy Men", Journal of Sports Science and Medicin, 12, pp.502~511 (2013)
  53. Sijie, T., "High intensity interval exercise training in overweight young women", The Journal of sports medicine and physical fitness, 52(3), pp.255~262 (2012)
  54. TaheriChadorneshin, H., "Comparing sprint and endurance training on anxiety, depression and its relation with brain-derived neurotrophic factor in rats", Behavioural brain research, 329, pp.1~5 (2017)
  55. Thoms, G., "Serum deyhydroepiandrosterone sulfate levels as an individual marker", Journal of clinical endocrinology and metabolism, 79(5), pp.1273~1276 (1994)
  56. Tsuchida, A., "Brainderived neurotrophic factor ameliorates lipid metabolism in diabetic mice", Diabetes, obesity and metabolism, 4(4), pp.262~269 (2002)
  57. Tsuchida, A., "Acute effects of brain-derived neurotrophic factor on energy expenditure in obese diabetic mice", International journal of obesity, 25(9), pp.1286~ (2001)
  58. Schwarz, A. J., "Acute effect of brief low-and high-intensity exercise on circulating insulin-like growth factor(IGF)I, I I, a nd I GF-b niding p rotein-3 and its proteolysis in young healthy men", The Journal of Clinical Endocrinology and Metabolis, 81(10), pp.3492~3497 (1996)
  59. Vega, S. R., "Acute BDNF and cortisol response to low intensity exercise and following ramp incremental exercise to exhaustion in humans", Brain research, 1121(1), pp.59~65 (2006)
  60. Walsh JJ, "Fasting and exercise differentially regulate BDNF mRNA expression in human skeletal muscle", Applied Physiology, Nutrition, and Metabolism, 40(1), pp.96~98 (2015)
  61. Willis, L. H., "Effects of aerobic and", or resistance training on body mass and fat mass in overweight or obese adults, 2012, pp.113(12), 1831~1837
  62. 윤장근, "Effects of 16-week spinning and bicycle exercise on body composition, physical fitness and blood variables of middle school students", Journal of exercise rehabilitation, 13(4), pp.400~404 (2017), 한국운동재활학회
  63. Zoladz, J. A., "Endurance training increases plasma brain-derived neurotrophic factor concentration in young healthy men", Journal of Physiology and Pharmacology, 59(Suppl 7), pp.119~132 (2008)

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