염생식물 갯질경이의 Peroxynitrite 소거 활성
Peroxynitrite-scavenging Activity of the Halophyte Limonium tetragonum
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초록
Crude extracts of Limonium tetragonum and their solvent-partitioned fractions were evaluated for their potential to scavenge authentic ONOO−, and ONOO− derived from 3-morpholinosydnonimine (SIN-1). Four flavonol glycosides (1-4) were isolated by activity-guided separation. Their chemical structures were elucidated by extensive 2 D NMR experiments and by comparison with published spectral data. These compounds were also estimated for their peroxynitrite scavenging effects. The scavenging ratios of compounds 1-4 on authentic ONOO− were 56, 37, 56, and 54%, respectively, at a concentration of 1 μM. On the other hand, the inbihition ratios of compounds 1-4 against ONOO− generation from SIN-1 were 59, 39, 44, and 54% at the same concentration, respectively.
Abstract
Crude extracts of Limonium tetragonum and their solvent-partitioned fractions were evaluated for their potential to scavenge authentic ONOO−, and ONOO− derived from 3-morpholinosydnonimine (SIN-1). Four flavonol glycosides (1-4) were isolated by activity-guided separation. Their chemical structures were elucidated by extensive 2 D NMR experiments and by comparison with published spectral data. These compounds were also estimated for their peroxynitrite scavenging effects. The scavenging ratios of compounds 1-4 on authentic ONOO− were 56, 37, 56, and 54%, respectively, at a concentration of 1 μM. On the other hand, the inbihition ratios of compounds 1-4 against ONOO− generation from SIN-1 were 59, 39, 44, and 54% at the same concentration, respectively.
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