삼채 뿌리 추출물 및 분획물의 항균 및 항산화 활성
Antimicrobial and Antioxidant Activity of Allium hookeri Root Extract and its Fractions
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In this study we investigated antimicrobial and antioxidant activities of A. hookeri root extract and itsfractions. Ethanol extract and n-hexane (HE) and methylene chloride (MC) fractions showed antimicrobialeffect against microbes causing skin troubles such as pimple, atopic dermatitis and dandruff. Minimuminhibitory concentration (MIC) of HE fraction against Propionibacterium acnes (P. acnes ), Malassezia furfur(M. furfur ), and Staphylococcus aureus (S. aureus ) were 2.5 mg/mL, 0.6 mg/mL and 0.2 mg/mL respectively. MIC of MC fraction against P. acnes , S. aureus and M. furfur were 3.0 mg/mL, 0.7 mg/mL and 0.3 mg/mLrespectively. In addition, they showed antioxidant effect in DPPH assay. The half maximum scavengingconcentrations (SC50) of ethanol extract and MC and EA fraction were 0.45 mg/mL, 0.1 mg/mL and 0.15mg/mL respectively. These results suggest that A. hookeri root extract and its fractions be a new functionalcosmetic ingredient with antioxidant and antimicrobial activity.
Abstract
In this study we investigated antimicrobial and antioxidant activities of A. hookeri root extract and itsfractions. Ethanol extract and n-hexane (HE) and methylene chloride (MC) fractions showed antimicrobialeffect against microbes causing skin troubles such as pimple, atopic dermatitis and dandruff. Minimuminhibitory concentration (MIC) of HE fraction against Propionibacterium acnes (P. acnes ), Malassezia furfur(M. furfur ), and Staphylococcus aureus (S. aureus ) were 2.5 mg/mL, 0.6 mg/mL and 0.2 mg/mL respectively. MIC of MC fraction against P. acnes , S. aureus and M. furfur were 3.0 mg/mL, 0.7 mg/mL and 0.3 mg/mLrespectively. In addition, they showed antioxidant effect in DPPH assay. The half maximum scavengingconcentrations (SC50) of ethanol extract and MC and EA fraction were 0.45 mg/mL, 0.1 mg/mL and 0.15mg/mL respectively. These results suggest that A. hookeri root extract and its fractions be a new functionalcosmetic ingredient with antioxidant and antimicrobial activity.
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