A Convergence Study on the Effects of Improving Buckwheat Dietary Fiber in Mice with Hyperlipidemia and Oxidative Stress
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
The effect of buckwheat dietary fiber (BDF) as hypolipidemic and antioxidant agent were determined in C57BL/6 mice fed a high fat diet (HFD) with different doses of 500 (low, BDF-L) or 1,000 (high, BDF-H) mg/kg of body weight, compared with the HFD-diet control group (HFD). The negative control group (ND) was fed the basal diet. Body weights in the BDF-L and BDF-H groups were significantly decreased as compared to those in the HFD group (p<0.05). BDF also improved the lipid profile in a dose-dependent manner; serum lipid profiles and levels of insulin, glucose, and free fatty acid were significantly decreased in the BDF-L and BDF-H groups, whereas HDL-C and adiponectin significantly increased as compared to the HFD group (p<0.05). Meanwhile, BDF lowered serum malondialdehyde (MDA) in comparison with the HFD group (p<0.05). The results demonstrate that the intake of BDF might prevent obesity and its related metabolic disorders by inducing dyslipidemia and oxidative stress.
Abstract
The effect of buckwheat dietary fiber (BDF) as hypolipidemic and antioxidant agent were determined in C57BL/6 mice fed a high fat diet (HFD) with different doses of 500 (low, BDF-L) or 1,000 (high, BDF-H) mg/kg of body weight, compared with the HFD-diet control group (HFD). The negative control group (ND) was fed the basal diet. Body weights in the BDF-L and BDF-H groups were significantly decreased as compared to those in the HFD group (p<0.05). BDF also improved the lipid profile in a dose-dependent manner; serum lipid profiles and levels of insulin, glucose, and free fatty acid were significantly decreased in the BDF-L and BDF-H groups, whereas HDL-C and adiponectin significantly increased as compared to the HFD group (p<0.05). Meanwhile, BDF lowered serum malondialdehyde (MDA) in comparison with the HFD group (p<0.05). The results demonstrate that the intake of BDF might prevent obesity and its related metabolic disorders by inducing dyslipidemia and oxidative stress.
참고문헌 (22)
- C. I. Abuajah, "Functional components and medicinal properties of food : a review", Journal of Food Science and Technology, 52(5), pp.2522~2529 (2015)
- M. Saxena, "Phytochemistry of medicinal plants", Journal of Pharmacognosy and Phytochemistry, 6(1), pp.168~182 (2013)
- M. Miao, "Phytonutrients for controlling starch digestion : Evaluation of grape skin extract", Food Chemistry, 145, pp.205~211 (2014)
- F. Zhu, "Effect of phytochemical extracts on the pasting, thermal, and gelling properties of wheat starch", Food Chemistry, 112(4), pp.919~923 (2009)
- F. Zhu, "Effect of phenolic compounds on the pasting and textural properties of wheat starch", Starch-Stärke, 60(11), pp.609~616 (2008)
- F. Barros, "Interaction of tannins and other sorghum phenolic compounds with starch and effects on in vitro starch digestibility", Journal of Agricultural and Food Chemistry, 60(46), pp.11609~11617 (2012)
- Y. Chai, "Interaction between amylose and tea polyphenols modulates the postprandial glycemic response to high-amylose maize starch", Journal of Agricultural and Food Chemistry, 61(36), pp.8608~8615 (2013)
- M. Chopra, "Nonalcoholic red wine extract and quercetin inhibit LDL oxidation without affecting plasma antioxidant vitamin and carotenoid concentrations", Clinical Chemistry, 46(8), pp.1162~1170 (2000)
- D. R. Ferry, "Phase I clinical trial of the flavonoid quercetin : pharmacokinetics and evidence for in vivo tyrosine kinase inhibition", Clinical Cancer Research, 2(4), pp.659~668 (1996)
- anthracene-induced mammary cancer in rats, "Carcinogenesis", 1996, 1305~1311
- Y. Q. Li, "Comparative evaluation of quercetin, isoquercetin and rutin as inhibitors of α-glucosidase", Journal of Agricultural and Food Chemistry, 57(24), pp.11463~11468 (2009)
- L. Zhang, "Preparation, physicochemical characterization and in vitro digestibility on solid complex of maize starches with quercetin", LWT-Food Science and Technology, 44(3), pp.787~792
- C. S. Brennan., "Dietary fibre, glycaemic response, and diabetes", Molecular Nutrition and Food Research, 49(6), pp.560~570 (2005)
- I. K Oh, "In vitro starch digestion and cake quality : impact of the ratio of soluble and insoluble dietary fiber", International Journal of Biological Macromolecules, 63, pp.98~103 (2014)
- M. Minekus, "A standardised static in vitro digestion method suitable for food–an international consensus", Food and Function, 5(6), pp.1113~1124 (2014)
- I. Goñi, "A starch hydrolysis procedure to estimate glycemic index", Nutrition Research, 17(3), pp.427~437 (1997)
- S. Shobana, "Composition and enzyme inhibitory properties of finger millet (Eleusine coracana L.)seed coat phenolics: Mode of inhibition of α-glucosidase and pancreatic amylase", Food Chemistry, 115(4), pp.1268~1273 (2009)
- A. S. Cho, "Chlorogenic acid exhibits anti-obesity property and improves lipid metabolism in high-fat diet-induced-obese mice", Food and Chemical Toxicology, 48, pp.937~943 (2010)
- Y. Hu, "Tartary buckwheat fl avonoids ameliorate high fructose-induced insulin resistance and oxidative stress associated with the insulin signaling and Nrf2", HO-1pathways in mice, 2017, pp.8, 2803~2816
- C. C. Lee, "Fagopyrum tataricum(Buckwheat)improved high-glucose induced insulin resistance in mouse hepatocytes and diabetes in fructose-rich diet-induced mice", Experimental Diabetes Research, 2012, pp.375673~375683 (2012)
- Y. Nie, "Differential protective effects of polyphenol extracts from apple peels and fleshes against acute CCl4-induced liver damage in mice", Food & Function, 6, pp.513~524 (2015)
- M. A. Mansour., "Protective effects of thymoquinone and desferrioxamine against hepatotoxicity of carbon tetrachloride in mice", Life Science, 66, pp.2583~2591 (2000)