방사성 히알루론산 합성
Synthesis of 125I-Labeled Hyaluronic Acid
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초록
Hyaluronic acid is a disaccharide polymer that consists of glucuronic acid and Nacetylglucosamine,and is a glycosaminoglycan. It is widely distributed in animal connectivetissue, coexisting with chondroitin sulfate. It forms viscous secretions or gel by bonding to proteinin the body, and thus maintains and lubricates tissue structures. In addition, its antibioticproperties are applied to cosmetics and pharmaceuticals. Therefore, it has recently been an objectof great interest at cosmetic and pharmaceutical companies. 125I has a longer half-life (59.4 days)than many other radioisotopes, and is therefore useful to long-term studies. In this study, a facileand efficient procedure for the synthesis of 125I-labeled hyaluronic acid has been designed for invivo imaging and pharmacokinetic studies of hyaluronic acid, which are required for the developmentof new drugs.
Abstract
Hyaluronic acid is a disaccharide polymer that consists of glucuronic acid and Nacetylglucosamine,and is a glycosaminoglycan. It is widely distributed in animal connectivetissue, coexisting with chondroitin sulfate. It forms viscous secretions or gel by bonding to proteinin the body, and thus maintains and lubricates tissue structures. In addition, its antibioticproperties are applied to cosmetics and pharmaceuticals. Therefore, it has recently been an objectof great interest at cosmetic and pharmaceutical companies. 125I has a longer half-life (59.4 days)than many other radioisotopes, and is therefore useful to long-term studies. In this study, a facileand efficient procedure for the synthesis of 125I-labeled hyaluronic acid has been designed for invivo imaging and pharmacokinetic studies of hyaluronic acid, which are required for the developmentof new drugs.
참고문헌 (14)
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