분자영상용 방사성 금 나노입자 합성
Synthesis of 125I-Labeled Gold Nanoparticles for a Molecular Imaging
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Gold nanoparticles (GNPs) have led to the development of a new field in the diagnosisand treatment of diseases such as cancer. An efficient synthesis of gold nanoparticles within therange of 8~57 nm was established by γ-ray irradiation. The good point of a radiation-basedmethod is the production of gold nanoparticles with a higher concentration and narrower sizedistribution compared with conventional methods. The size of gold nanoparticles was controlledusing two methods. : (i) varying the γ-ray irradiation dose of 10 to 25 kGy and (ii) varying the concentrationof HAuCl4 solution from 4 to 40 mM. In addition, the GNPs were radiolabeled using[125I]NaI in a simple and fast manner with high yields. The produced gold nanoparticles were characterizedusing a transmission electron microscopy (TEM), a UV-visible spectrophotometer, anda radio-TLC imaging scanner. From these results, these radiolabeled GNPs can be applicable fora radioisotope tag of biomolecules.
Abstract
Gold nanoparticles (GNPs) have led to the development of a new field in the diagnosisand treatment of diseases such as cancer. An efficient synthesis of gold nanoparticles within therange of 8~57 nm was established by γ-ray irradiation. The good point of a radiation-basedmethod is the production of gold nanoparticles with a higher concentration and narrower sizedistribution compared with conventional methods. The size of gold nanoparticles was controlledusing two methods. : (i) varying the γ-ray irradiation dose of 10 to 25 kGy and (ii) varying the concentrationof HAuCl4 solution from 4 to 40 mM. In addition, the GNPs were radiolabeled using[125I]NaI in a simple and fast manner with high yields. The produced gold nanoparticles were characterizedusing a transmission electron microscopy (TEM), a UV-visible spectrophotometer, anda radio-TLC imaging scanner. From these results, these radiolabeled GNPs can be applicable fora radioisotope tag of biomolecules.
참고문헌 (15)
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