납 표준물질을 이용한 방사성동위원소 Thallium-201의 화학적 분리공정 개발
Development of Chemical Separation Process for Thallium-201 Radioisotope with Lead Standard Material
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Thallium-201 (201Tl) is a medical radioisotope which emits gamma rays when it decays andused in myocardial perfusion scans in single-photon emission tomography due to its similar propertiesto potassium. Currently, the Korea Institute of Radiological & Medical Sciences is the only institutionproducing 201Tl in Korea, and optimization of 201Tl production research is necessary to meet supplycompared to domestic demand. To this end, technical analysis of plating target production and chemicalseparation methods essential for 201Tl production research is conducted. It deals with the process ofgenerating and separating 201Tl radioisotope and target production, It can be generated through a nuclearreaction such as natHg(p,xn)201Tl, 201Hg(p,n)201Tl, natPb(p,xn)201Bi → 201Pb → 201Tl, 205Tl(p,5n)201Pb → 201Tl,and considering impure nuclide generated simultaneously with the use of proton beam energy of 35MeV or less, it is intended to be produced using the 203Tl(p,3n)201Pb → 201Tl nuclear reaction. In particular,the chemical separation of Tl is a very important element, and the chemical separation methodsthat can separate it is broadly divided into four types, including solid phase extraction, liquid-liquid,electrochemical, and ion exchange membrane separation. Some chemical separations require additionalseparation steps, such as methods using selective adsorption. Therefore, this technical report describesfour chemical separation methods and seeks to separate high-purity 201Tl using a method withoutadditional separation steps
Abstract
Thallium-201 (201Tl) is a medical radioisotope which emits gamma rays when it decays andused in myocardial perfusion scans in single-photon emission tomography due to its similar propertiesto potassium. Currently, the Korea Institute of Radiological & Medical Sciences is the only institutionproducing 201Tl in Korea, and optimization of 201Tl production research is necessary to meet supplycompared to domestic demand. To this end, technical analysis of plating target production and chemicalseparation methods essential for 201Tl production research is conducted. It deals with the process ofgenerating and separating 201Tl radioisotope and target production, It can be generated through a nuclearreaction such as natHg(p,xn)201Tl, 201Hg(p,n)201Tl, natPb(p,xn)201Bi → 201Pb → 201Tl, 205Tl(p,5n)201Pb → 201Tl,and considering impure nuclide generated simultaneously with the use of proton beam energy of 35MeV or less, it is intended to be produced using the 203Tl(p,3n)201Pb → 201Tl nuclear reaction. In particular,the chemical separation of Tl is a very important element, and the chemical separation methodsthat can separate it is broadly divided into four types, including solid phase extraction, liquid-liquid,electrochemical, and ion exchange membrane separation. Some chemical separations require additionalseparation steps, such as methods using selective adsorption. Therefore, this technical report describesfour chemical separation methods and seeks to separate high-purity 201Tl using a method withoutadditional separation steps
참고문헌 (12)
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