High Dietary Sodium Intake Assessed by 24-hour Urine Specimen Increase Urinary Calcium Excretion and Bone Resorption Marker
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Background: The average dietary sodium intake of Koreans is 2.6 times higher than theWorld Health Organization’s recommended amount. The effect of a diet high in sodiumon the skeletal system, especially osteoporosis, has not previously been examined in Ko-rean postmenopausal women with low bone mass. We assessed the daily sodium in-take, and determined the impact of sodium intake on urinary calcium excretion andbone resorption marker. Methods: A retrospective review of medical records was per-formed for 86 postmenopausal subjects who were initially diagnosed with osteopeniaor osteoporosis at the health promotion center. They were subsequently referred to theDivision of Endocrinology and Metabolism between 2010 and 2013. All subjects com-pleted a modified food frequency questionnaire. Twenty-four hour urine collection forsodium, calcium and creatinine excretion, and serum C-terminal telopeptides of type Icollagen (CTX-I) were also obtained. Results: The average amount of daily sodium andcalcium intake were 3,466 mg and 813 mg, respectively. Average dietary sodium intakeand 24-hour urinary sodium excretion showed significant positive linear correlation (r=0.29, P=0.006). There was also a significant positive linear correlation between 24-hoururine sodium and calcium excretion (r=0.42, P<0.001); CTX-I and 24-hour urinary calci-um excretion (r=0.29, P=0.007). Conclusions: Excessive sodium intake assessed by 24-hour urine specimen is associated with high calcium excretion in urine. High calcium ex-cretion is also related to increasing bone resorption marker.
Abstract
Background: The average dietary sodium intake of Koreans is 2.6 times higher than theWorld Health Organization’s recommended amount. The effect of a diet high in sodiumon the skeletal system, especially osteoporosis, has not previously been examined in Ko-rean postmenopausal women with low bone mass. We assessed the daily sodium in-take, and determined the impact of sodium intake on urinary calcium excretion andbone resorption marker. Methods: A retrospective review of medical records was per-formed for 86 postmenopausal subjects who were initially diagnosed with osteopeniaor osteoporosis at the health promotion center. They were subsequently referred to theDivision of Endocrinology and Metabolism between 2010 and 2013. All subjects com-pleted a modified food frequency questionnaire. Twenty-four hour urine collection forsodium, calcium and creatinine excretion, and serum C-terminal telopeptides of type Icollagen (CTX-I) were also obtained. Results: The average amount of daily sodium andcalcium intake were 3,466 mg and 813 mg, respectively. Average dietary sodium intakeand 24-hour urinary sodium excretion showed significant positive linear correlation (r=0.29, P=0.006). There was also a significant positive linear correlation between 24-hoururine sodium and calcium excretion (r=0.42, P<0.001); CTX-I and 24-hour urinary calci-um excretion (r=0.29, P=0.007). Conclusions: Excessive sodium intake assessed by 24-hour urine specimen is associated with high calcium excretion in urine. High calcium ex-cretion is also related to increasing bone resorption marker.
참고문헌 (21)
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