Microarray Analysis of Gene Expression Reveals that Cyclo-oxygenase-2 Gene Therapy Up-regulates Hematopoiesis and Down-regulates Inflammation During Endochondral Bone Fracture Healing

키워드

참고문헌 (45)

1. Bolander ME., "Regulation of fracture repair by growth factors", Proc Soc Exp Biol Med., 200, pp.165~170 (1992)
2. Axelrad TW., "New technologies for the enhancement of skeletal repair", Injury., 38(Suppl 1), pp.S49~62 (2007)
3. Hadjiargyrou M., "Transcriptional profiling of bone regeneration. Insight into the molecular complexity of wound repair", J Biol Chem., 277, pp.30177~30182 (2002)
4. Li X., "Early signals for fracture healing", J Cell Biochem., 95, pp.189~205 (2005)
5. Simon AM., "Cyclo-oxygenase 2 function is essential for bone fracture healing", J Bone Miner Res., 17, pp.963~976 (2002)
6. Zhang X., "Cyclooxygenase-2 regulates mesenchymal cell differentiation into the osteoblast lineage and is critically involved in bone repair", J Clin Invest., 109, pp.1405~1415 (2002)
7. Naik AA., "Reduced COX-2 expression in aged mice is associated with impaired fracture healing", J Bone Miner Res., 24, pp.251~264 (2009)
8. Tilley SL., "Mixed messages: modulation of inflammation and immune responses by prostaglandins and thromboxanes", J Clin Invest., 108, pp.15~23 (2001)
9. Zhang M., "EP1(-", -) mice have enhanced osteoblast differentiation and accelerated fracture repair, 2011, pp.26, 792~802
10. Paralkar VM., "An EP2 receptor-selective prostaglandin E2 agonist induces bone healing", Proc Natl Acad Sci U S A., 100, pp.6736~6740 (2003)
11. Xie C., "Rescue of impaired fracture healing in COX-2-", - mice via activation of prostaglandin E2 receptor subtype 4, 2009, pp.175, 772~785
12. Rundle CH., "Retroviral-based gene therapy with cyclooxygenase-2 promotes the union of bony callus tissues and accelerates fracture healing in the rat", J Gene Med., 10, pp.229~241 (2008)
13. Xie C., "COX-2 from the injury milieu is critical for the initiation of periosteal progenitor cell mediated bone healing", Bone., 43, pp.1075~1083 (2008)
14. Amano H., "Host prostaglandin E(2)-EP3 signaling regulates tumor-associated angiogenesis and tumor growth", J Exp Med., 197, pp.221~232 (2003)
15. Katoh H., "COX-2 and prostaglandin EP3", EP4 signaling regulate the tumor stromal proangiogenic microenvironment via CXCL12-CXCR4 chemokine systems, 2010, pp.176, 1469~1483
16. Mark H., "Microvascular invasion during endochondral ossification in experimental fractures in rats", Bone., 35, pp.535~542 (2004)
17. Bonnarens F., "Production of a standard closed fracture in laboratory animal bone", J Orthop Res., 2, pp.97~101 (1984)
18. Robertson G., "Alteration of femoral bone morphology and density in COX-2-", - mice, 2006, pp.39, 767~772
19. Lau KH., "Cellular and molecular mechanisms of accelerated fracture healing by COX2 gene therapy: studies in a mouse model of multiple fractures", Bone., 53, pp.369~381 (2013)
20. Gerstenfeld LC., "Differential inhibition of fracture healing by non-selective and cyclooxygenase-2 selective non-steroidal anti-inflammatory drugs", J Orthop Res., 21, pp.670~675 (2003)
21. Subramanian A., "Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles", Proc Natl Acad Sci U S A., 102, pp.15545~15550 (2005)
22. Ma S., "Ikaros and Aiolos inhibit pre-B-cell proliferation by directly suppressing c-Myc expression", Mol Cell Biol., 30, pp.4149~4158 (2010)
23. Fujita H., "Prevention of bone loss after ovariectomy in mice with preferential overexpression of the transcription factor paired box-5 in osteoblasts", Biol Pharm Bull., 36, pp.481~484 (2013)
24. Pang CJ., "Kruppel-like factor 1 (KLF1), KLF2, and Myc control a regulatory network essential for embryonic erythropoiesis", Mol Cell Biol., 32, pp.2628~2644 (2012)
25. Hosono K., "Identification and characterization of a novel gene family YPEL in a wide spectrum of eukaryotic species", Gene., 340, pp.31~43 (2004)
26. Förster R., "A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen", Cell., 87, pp.1037~1047 (1996)
27. Ouyang W., "TGF-beta cytokine signaling promotes CD8+ T cell development and low-affinity CD4+ T cell homeostasis by regulation of interleukin-7 receptor alpha expression", Immunity., 39, pp.335~346 (2013)
28. Dufour JH., "IFN-gamma-inducible protein 10 (IP-10; CXCL10)-deficient mice reveal a role for IP-10 in effector T cell generation and trafficking", J Immunol., 168, pp.3195~3204 (2002)
29. Peperzak V., "CD8+ T cells produce the chemokine CXCL10 in response to CD27", CD70 costimulation to promote generation of the CD8+ effector T cell pool, 2013, pp.191, 3025~3036
30. Van Damme J., "Structural and functional identification of two human, tumor-derived monocyte chemotactic proteins (MCP-2 and MCP-3) belonging to the chemokine family", J Exp Med., 176, pp.59~65 (1992)
31. Bais M., "Transcriptional analysis of fracture healing and the induction of embryonic stem cell-related genes", PLoS One., 4, pp.e5393~ (2009)
32. North TE., "Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis", Nature., 447, pp.1007~1011 (2007)
33. Pelus LM., "Pleiotropic effects of prostaglandin E2 in hematopoiesis; prostaglandin E2 and other eicosanoids regulate hematopoietic stem and progenitor cell function", Prostaglandins Other Lipid Mediat., 96, pp.3~9 (2011)
34. Salcedo R., "Angiogenic effects of prostaglandin E2 are mediated by up-regulation of CXCR4 on human microvascular endothelial cells", Blood., 102, pp.1966~1977 (2003)
35. Sinha P., "Prostaglandin E2 promotes tumor progression by inducing myeloid-derived suppressor cells", Cancer Res., 67, pp.4507~4513 (2007)
36. Gabrilovich DI., "Myeloid-derived suppressor cells as regulators of the immune system", Nat Rev Immunol., 9, pp.162~174 (2009)
37. Street J., "Vascular endothelial growth factor stimulates bone repair by promoting angiogenesis and bone turnover", Proc Natl Acad Sci U S A., 99, pp.9656~9661 (2002)
38. Irie A., "Third isoform of the prostaglandin-E-receptor EP3 subtype with different C-terminal tail coupling to both stimulation and inhibition of adenylate cyclase", Eur J Biochem., 217, pp.313~318 (1993)
39. Goulet JL., "E-prostanoid-3 receptors mediate the proinflammatory actions of prostaglandin E2 in acute cutaneous inflammation", J Immunol., 173, pp.1321~1326 (2004)
40. Jain S., "Prostaglandin E2 regulates tumor angiogenesis in prostate cancer", Cancer Res., 68, pp.7750~7759 (2008)
41. Ueno T., "Recruited bone marrow cells expressing the EP3 prostaglandin E receptor subtype enhance angiogenesis during chronic inflammation", Biomed Pharmacother., 64, pp.93~100 (2010)
42. Kamoshita E., "Recruitment of a prostaglandin E receptor subtype, EP3-expressing bone marrow cells is crucial in wound-induced angiogenesis", Am J Pathol., 169, pp.1458~1472 (2006)
43. Arikawa T., "Regulation of bone morphogenetic protein-2 expression by endogenous prostaglandin E2 in human mesenchymal stem cells", J Cell Physiol., 200, pp.400~406 (2004)
44. Colnot C., "Altered fracture repair in the absence of MMP9", Development., 130, pp.4123~4133 (2003)
45. Amano H., "Roles of a prostaglandin E-type receptor, EP3, in upregulation of matrix metalloproteinase-9 and vascular endothelial growth factor during enhancement of tumor metastasis", Cancer Sci., 100, pp.2318~1324 (2009)

관련 논문AI추천