Calcium and Vitamin D Supplementations: 2015 Position Statement of the Korean Society for Bone and Mineral Research
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Calcium and vitamin D are essential components for bone health, thus calcium and vitamin D supplementation is an important strategy in the management of osteoporosis. However, the benefit of calcium and vitamin D supplementation on bone health is still controversial. Moreover, potentially harmful effects of excessive calcium supplementation on cardiovascular health are recently suggested. Too high a level of vitamin D has been also reported to have several, possibly related, harmful events. Korea is well known for low dietary calcium intake and vitamin D deficiency in its population. This position statement developed the following recommendation for adequate levels of calcium and vitamin D intake in Korean, postmenopausal women and men older than 50 years: Adequate calcium intake and optimal vitamin D level are essential for preventing and treating osteoporosis in postmenopausal women and men older than 50 years. We recommend a daily calcium intake of 800 to 1,000 mg/day. Food remains the best source of calcium; however calcium supplements should be considered when dietary intake of calcium is inadequate. We recommend dietary vitamin D intake of more than 800 IU per day, a level which appears to reduce the risk of fractures. When vitamin D deficiency is suspected, serum 25-hydroxy-vitamin D (25-[OH]D) level should be tested. We suggest that a serum 25-(OH)D level greater than 20 ng/mL is generally appropriate for prevention of osteoporosis. However, a serum 25-(OH)D level greater than 30 ng/mL is probably helpful for management of osteoporosis and prevention of fractures.
Abstract
Calcium and vitamin D are essential components for bone health, thus calcium and vitamin D supplementation is an important strategy in the management of osteoporosis. However, the benefit of calcium and vitamin D supplementation on bone health is still controversial. Moreover, potentially harmful effects of excessive calcium supplementation on cardiovascular health are recently suggested. Too high a level of vitamin D has been also reported to have several, possibly related, harmful events. Korea is well known for low dietary calcium intake and vitamin D deficiency in its population. This position statement developed the following recommendation for adequate levels of calcium and vitamin D intake in Korean, postmenopausal women and men older than 50 years: Adequate calcium intake and optimal vitamin D level are essential for preventing and treating osteoporosis in postmenopausal women and men older than 50 years. We recommend a daily calcium intake of 800 to 1,000 mg/day. Food remains the best source of calcium; however calcium supplements should be considered when dietary intake of calcium is inadequate. We recommend dietary vitamin D intake of more than 800 IU per day, a level which appears to reduce the risk of fractures. When vitamin D deficiency is suspected, serum 25-hydroxy-vitamin D (25-[OH]D) level should be tested. We suggest that a serum 25-(OH)D level greater than 20 ng/mL is generally appropriate for prevention of osteoporosis. However, a serum 25-(OH)D level greater than 30 ng/mL is probably helpful for management of osteoporosis and prevention of fractures.
참고문헌 (50)
- Krall EA, "Heritable and life-style determinants of bone mineral density", J Bone Miner Res, 8, pp.1~9 (1993)
- Chevalley T, "Effects of calcium supplements on femoral bone mineral density and vertebral fracture rate in vitamin-D-replete elderly patients", Osteoporos Int, 4, pp.245~252 (1994)
- Varenna M, "Effects of dietary calcium intake on body weight and prevalence of osteoporosis in early postmenopausal women", Am J Clin Nutr, 86, pp.639~644 (2007)
- Compston J, "Diagnosis and management of osteoporosis in postmenopausal women and older men in the UK : National Osteoporosis Guideline Group(NOGG)update 2013", Maturitas, 75, pp.392~396 (2013)
- Bischoff-Ferrari HA, "Calcium intake and hip fracture risk in men and women : a meta-analysis of prospective cohort studies and randomized controlled trials", Am J Clin Nutr, 86, pp.1780~1790 (2007)
- Shea B, "Meta-analyses of therapies for postmenopausal osteoporosis. VII. Meta-analysis of calcium supplementation for the prevention of postmenopausal osteoporosis", Endocr Rev, 23, pp.552~559 (2002)
- Michaëlsson K, "Long term calcium intake and rates of all cause and cardiovascular mortality: community based prospective longitudinal cohort study", BMJ, 346, pp.f228~ (2013)
- Bolland MJ, "Effect of calcium supplements on risk of myocardial infarction and cardiovascular events: meta-analysis", BMJ, 341, pp.c3691~ (2010)
- Bolland MJ, "Vascular events in healthy older women receiving calcium supplementation: randomised controlled trial", BMJ, 336, pp.262~266 (2008)
- Umesawa M, "Dietary calcium intake and risks of stroke, its subtypes, and coronary heart disease in Japanese: the JPHC Study Cohort I", Stroke, 39, pp.2449~2456 (2008)
- 신찬수, "The Risks and Benefits of Calcium Supplementation", Endocrinology and Metabolism, 30(1), pp.27~34 (2015), 대한내분비학회
- Bikle DD, "Vitamin D and bone", Curr Osteoporos Rep, 10, pp.151~159 (2012)
- Forman JP, "Plasma 25-hydroxyvitamin D levels and risk of incident hypertension", Hypertension, 49, pp.1063~1069 (2007)
- Giovannucci E, "25-hydroxyvitamin D and risk of myocardial infarction in men: a prospective study", Arch Intern Med, 168, pp.1174~1180 (2008)
- Mattila C, "Serum 25-hydroxyvitamin D concentration and subsequent risk of type 2 diabetes", Diabetes Care, 30, pp.2569~2570 (2007)
- Choi HS, "Low serum vitamin D is associated with high risk of diabetes in Korean adults", J Nutr, 141, pp.1524~1528 (2011)
- Giovannucci E, "Prospective study of predictors of vitamin D status and cancer incidence and mortality in men", J Natl Cancer Inst, 98, pp.451~459 (2006)
- Laaksi I, "An association of serum vitamin D concentrations <40 nmol", L with acute respiratory tract infection in young Finnish men, 2007, pp.86, 714~717
- Kamen D, "Vitamin D in systemic lupus erythematosus", Curr Opin Rheumatol, 20, pp.532~537 (2008)
- 최한석, "Vitamin D Status in Korea", Endocrinology and Metabolism, 28(1), pp.12~16 (2013), 대한내분비학회
- Lips P, "The prevalence of vitamin D inadequacy amongst women with osteoporosis : an international epidemiological investigation", J Intern Med, 260, pp.245~254 (2006)
- Choi HS, "Vitamin D insufficiency in Korea--a greater threat to younger generation : the Korea National Health and Nutrition Examination Survey(KNHANES)2008", J Clin Endocrinol Metab, 96, pp.643~651 (2011)
- 홍희옥, "Effects of calcium intake, milk and dairy product intake, and blood vitamin D level on osteoporosis risk in Korean adults: analysis of the 2008 and 2009 Korea National Health and Nutrition Examination Survey", Nutrition Research and Practice, 7(5), pp.409~417 (2013), 한국영양학회
- Shin CS, "Prevalence and risk factors of osteoporosis in Korea: a community-based cohort study with lumbar spine and hip bone mineral density", Bone, 47, pp.378~387 (2010)
- Yang YJ, "Factors in relation to bone mineral density in Korean middle-aged and older men: 2008-2010 Korea National Health and Nutrition Examination Survey", Ann Nutr Metab, 64, pp.50~59 (2014)
- Joo NS, "Impact of calcium and vitamin D insufficiencies on serum parathyroid hormone and bone mineral density: analysis of the fourth and fifth Korea National Health and Nutrition Examination Survey (KNHANES IV-3, 2009 and KNHANES V-1, 2010)", J Bone Miner Res, 28, pp.764~770 (2013)
- Kim KM, "Interactions between dietary calcium intake and bone mineral density or bone geometry in a low calcium intake population (KNHANES IV 2008-2010)", J Clin Endocrinol Metab, 99, pp.2409~2417 (2014)
- Lau EM, "Milk supplementation of the diet of postmenopausal Chinese women on a low calcium intake retards bone loss", J Bone Miner Res, 16, pp.1704~1709 (2001)
- Nakamura K, "Effect of low-dose calcium supplements on bone loss in perimenopausal and postmenopausal Asian women : a randomized controlled trial", J Bone Miner Res, 27, pp.2264~2270 (2012)
- Wang X, "Dietary calcium intake and mortality risk from cardiovascular disease and all causes : a meta-analysis of prospective cohort studies", BMC Med, 12, pp.158~ (2014)
- Xiao Q, "Dietary and supplemental calcium intake and cardiovascular disease mortality : the National Institutes of Health-AARP diet and health study", JAMA Intern Med, 173, pp.639~646 (2013)
- Hsia J, "Calcium", vitamin D supplementation and cardiovascular events, 2007, pp.115, 846~854
- Bostick RM, "Relation of calcium, vitamin D, and dairy food intake to ischemic heart disease mortality among postmenopausal women", Am J Epidemiol, 149, pp.151~161 (1999)
- Challoumas D, "Effects of calcium intake on the cardiovascular system in postmenopausal women", Atherosclerosis, 231, pp.1~7 (2013)
- Uenishi K, "Calcium requirement estimated by balance study in elderly Japanese people", Osteoporos Int, 12, pp.858~863 (2001)
- Hunt CD, "Calcium requirements : new estimations for men and women by cross-sectional statistical analyses of calcium balance data from metabolic studies", Am J Clin Nutr, 86, pp.1054~1063 (2007)
- Priemel M, "Bone mineralization defects and vitamin D deficiency : histomorphometric analysis of iliac crest bone biopsies and circulating 25-hydroxyvitamin D in 675 patients", J Bone Miner Res, 25, pp.305~312 (2010)
- Hwang S, "Associations between serum 25-hydroxyvitamin D and bone mineral density and proximal femur geometry in Koreans : the Korean National Health and Nutrition Examination Survey(KNHANES)2008-2009", Osteoporos Int, 26, pp.163~171 (2015)
- Kuchuk NO, "Relationships of serum 25-hydroxyvitamin D to bone mineral density and serum parathyroid hormone and markers of bone turnover in older persons", J Clin Endocrinol Metab, 94, pp.1244~1250 (2009)
- Melhus H, "Plasma 25-hydroxyvitamin D levels and fracture risk in a community-based cohort of elderly men in Sweden", J Clin Endocrinol Metab, 95, pp.2637~2645 (2010)
- Ensrud KE, "Serum 25-hydroxyvitamin D levels and rate of hip bone loss in older men", J Clin Endocrinol Metab, 94, pp.2773~2780 (2009)
- Bischoff-Ferrari HA, "Benefit-risk assessment of vitamin D supplementation", Osteoporos Int, 21, pp.1121~1132 (2010)
- Tang BM, "Use of calcium or calcium in combination with vitamin D supplementation to prevent fractures and bone loss in people aged 50 years and older : a meta-analysis", Lancet, 370, pp.657~666 (2007)
- Bischoff-Ferrari HA, "A pooled analysis of vitamin D dose requirements for fracture prevention", N Engl J Med, 367, pp.40~49 (2012)
- Hathcock JN, "Risk assessment for vitamin D", Am J Clin Nutr, 85, pp.6~18 (2007)
- Wallace RB, "Urinary tract stone occurrence in the Women's Health Initiative (WHI) randomized clinical trial of calcium and vitamin D supplements", Am J Clin Nutr, 94, pp.270~277 (2011)
- Durup D, "A reverse J-shaped association of all-cause mortality with serum 25-hydroxyvitamin D in general practice : the CopD study", J Clin Endocrinol Metab, 97, pp.2644~2652 (2012)
- Durup D, "A Reverse J-Shaped Association Between Serum 25-Hydroxyvitamin D and Cardiovascular Disease Mortality : the CopD Study", J Clin Endocrinol Metab, 100, pp.2339~2346 (2015)
- Chowdhury R, "Vitamin D and risk of cause specific death: systematic review and meta-analysis of observational cohort and randomised intervention studies", BMJ, 348, pp.g1903~ (2014)
- Sousa Nanji L, "Analysis of the Cochrane Review: thrombolysis for acute deep vein thrombosis. Cochrane Database Syst Rev. 2014,1: CD002783", Acta Med Port, 28, pp.12~14 (2015)
