The Effect of Education and Vitamin D Supplementation on the Achievement of Optimal Vitamin D Level in Korean Postmenopausal Women
2
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
Background: Despite daily vitamin D recommendations, women with osteoporosis may not achieve optimal 25-hydroxy-vitamin D (25[OH]D) levels. We retrospectively evaluated the effect of education and vitamin D supplementation (1,000 IU/day) in Korean women with osteoporosis. Methods: Sixty-one women with osteoporosis who were taking cholecalciferol (800-1,000 IU/day) were enrolled during 2011 to 2012. Forty patients (education only, Edu group) were educated on the importance of >30 min sunlight exposure daily while taking vitamin D. Twenty-one patients (education with vitamin D supplementation, Add group) were prescribed 1,000 IU/day cholecalciferol (total 1,800-2,000 IU/day) plus education. Patients were divided into 3 groups according to serum 25(OH)D status: deficiency (<20 ng/mL), insufficiency (20-30 ng/mL), and sufficiency (≥30 ng/mL). Furthermore, 25(OH)D levels were compared at baseline and after intervention for 3 months. Results: The median (interquartile range) serum 25(OH)D concentration at baseline was 25.10 (18.95-33.60) ng/mL. The mean (±standard error) differences in 25(OH)D levels from baseline to post-intervention were 19.85±3.86 and 31.73±4.82 ng/mL in the Edu group and Add group, respectively. Eighteen patients (29.5%) had vitamin D deficiency, 25 (41.0%) had insufficiency, and 18 (29.5%) had sufficient levels. Optimal 25(OH)D (30 ng/mL or more) was achieved in 54.5% and 95.2% patients in the Edu group and Add group, respectively (P=0.003). Conclusions: We consider that vitamin D concentration should be measured on a regular basis in order to maintain an optimal level of vitamin D concentration, and education and supplementation is needed if not sufficient.
Abstract
Background: Despite daily vitamin D recommendations, women with osteoporosis may not achieve optimal 25-hydroxy-vitamin D (25[OH]D) levels. We retrospectively evaluated the effect of education and vitamin D supplementation (1,000 IU/day) in Korean women with osteoporosis. Methods: Sixty-one women with osteoporosis who were taking cholecalciferol (800-1,000 IU/day) were enrolled during 2011 to 2012. Forty patients (education only, Edu group) were educated on the importance of >30 min sunlight exposure daily while taking vitamin D. Twenty-one patients (education with vitamin D supplementation, Add group) were prescribed 1,000 IU/day cholecalciferol (total 1,800-2,000 IU/day) plus education. Patients were divided into 3 groups according to serum 25(OH)D status: deficiency (<20 ng/mL), insufficiency (20-30 ng/mL), and sufficiency (≥30 ng/mL). Furthermore, 25(OH)D levels were compared at baseline and after intervention for 3 months. Results: The median (interquartile range) serum 25(OH)D concentration at baseline was 25.10 (18.95-33.60) ng/mL. The mean (±standard error) differences in 25(OH)D levels from baseline to post-intervention were 19.85±3.86 and 31.73±4.82 ng/mL in the Edu group and Add group, respectively. Eighteen patients (29.5%) had vitamin D deficiency, 25 (41.0%) had insufficiency, and 18 (29.5%) had sufficient levels. Optimal 25(OH)D (30 ng/mL or more) was achieved in 54.5% and 95.2% patients in the Edu group and Add group, respectively (P=0.003). Conclusions: We consider that vitamin D concentration should be measured on a regular basis in order to maintain an optimal level of vitamin D concentration, and education and supplementation is needed if not sufficient.
참고문헌 (15)
- Holick MF, "Vitamin D deficiency", N Engl J Med, 357, pp.266~281 (2007)
- Parfitt AM, "Metabolic bone disease and clinically related disorders", pp.329~396 (1990), W.B. Saunders Company
- Sahota O, "Vitamin D insufficiency increases bone turnover markers and enhances bone loss at the hip in patients with established vertebral osteoporosis", Clin Endocrinol (Oxf), 51 (1995)
- Malavolta N, "The relationship of vitamin D status to bone mineral density in an Italian population of postmenopausal women", Osteoporos Int, 16, pp.1691~1697 (2005)
- 김경민, "Calcium and Vitamin D Supplementations: 2015 Position Statement of the Korean Society for Bone and Mineral Research", 대한골대사학회지, 22(4), pp.143~149 (2015), 대한골대사학회
- Dawson-Hughes B, "Estimates of optimal vitamin D status", Osteoporos Int, 16, pp.713~716 (2005)
- Choi EY, "25(OH)D status and demographic and lifestyle determinants of 25(OH)D among Korean adults", Asia Pac J Clin Nutr, 21, pp.526~535 (2012)
- 김진주, "Vitamin D Status and Response to Initial Vitamin D Supplementation in Korean Women with Osteoporosis", 대한골대사학회지, 21(4), pp.257~262 (2014), 대한골대사학회[DOI]
- Cannell JJ, "Use of vitamin D in clinical practice", Altern Med Rev, 13, pp.6~20 (2008)
- Leidig-Bruckner G, "Are commonly recommended dosages for vitamin D supplementation too low? Vitamin D status and effects of supplementation on serum 25-hydroxyvitamin D levels--an observational study during clinical practice conditions", Osteoporos Int, 22, pp.231~240 (2011)
- Bischoff-Ferrari HA, "Benefit-risk assessment of vitamin D supplementation", Osteoporos Int, 21, pp.1121~1132 (2010)
- Ryu OH, "A prospective randomized controlled trial of the effects of vitamin D supplementation on long-term glycemic control in type 2 diabetes mellitus of Korea", Endocr J, 61, pp.167~176 (2014)
- 류옥현, "The effect of high-dose vitamin D supplementation on insulin resistance and arterial stiffness in patients with type 2 diabetes", The Korean Journal of Internal Medicine, 29(5), pp.620~629 (2014), 대한내과학회[DOI]
- Ivorra J, "Vitamin D status in osteoporotic postmenopausal women taking oral recommended vitamin D supplementation", Med Clin (Barc), 138, pp.199~201 (2012)
- Gallagher JC, "Dose response to vitamin D supplementation in postmenopausal women: a randomized trial", Ann Intern Med, 156, pp.425~437 (2012)