Vitamin D Repletion in Korean Postmenopausal Women with Osteoporosis
2
조회
0
다운로드
4
인용
0
참고문헌
키워드
초록
Purpose: Up to 71% of South Korean postmenopausal women have vitamin D deficiency {serum 25-hydroxyvitamin D [25(OH)D] level <50 nmol/L}. Data on vitamin D supplementation was collected during the screening phase of an efficacy/safety study of denosumab in Korean postmenopausal women with osteoporosis. This report describes the effect of vitamin D supplementation on repletion to 25(OH)D levels ≥50 nmol/L in Korean postmenopausal women with osteoporosis. Materials and Methods: Vitamin D levels of Korean postmenopausal women (60–90 years old) were measured by extracting 25(OH)D2 and 25(OH)D3 from serum samples via protein precipitation and using liquid chromatography with tandem mass spectrometry detection. Calibration curves were constructed from the mass chromatograms to obtain total vitamin D levels. Subjectswith serum 25(OH)D levels <50 nmol/L were supplemented with 1000 IU of vitamin D tablets during the 2.5-month-long screening period. Dose, frequency, and duration were determined by the investigator. If repletion was achieved (≥50 nmol/L) on retest, subjects were eligible to be rescreened for study entry. Results: Of 371 subjects screened, 191 (52%) required vitamin D supplementation, and 88% (168 of 191) were successfully repleted. More than half of the subjects (58%) who were successfully repleted received doses of 2000 IU daily. The mean time to successful repletion was 31 days (standard deviation 8.4 days; range 11–48 days). Conclusion: Supplementation with daily median doses of 2000 IU vitamin D successfully repleted 88% of Korean postmenopausalwomen with osteoporosis within 48 days to a serum vitamin D level of 50 nmol/L.
Abstract
Purpose: Up to 71% of South Korean postmenopausal women have vitamin D deficiency {serum 25-hydroxyvitamin D [25(OH)D] level <50 nmol/L}. Data on vitamin D supplementation was collected during the screening phase of an efficacy/safety study of denosumab in Korean postmenopausal women with osteoporosis. This report describes the effect of vitamin D supplementation on repletion to 25(OH)D levels ≥50 nmol/L in Korean postmenopausal women with osteoporosis. Materials and Methods: Vitamin D levels of Korean postmenopausal women (60–90 years old) were measured by extracting 25(OH)D2 and 25(OH)D3 from serum samples via protein precipitation and using liquid chromatography with tandem mass spectrometry detection. Calibration curves were constructed from the mass chromatograms to obtain total vitamin D levels. Subjectswith serum 25(OH)D levels <50 nmol/L were supplemented with 1000 IU of vitamin D tablets during the 2.5-month-long screening period. Dose, frequency, and duration were determined by the investigator. If repletion was achieved (≥50 nmol/L) on retest, subjects were eligible to be rescreened for study entry. Results: Of 371 subjects screened, 191 (52%) required vitamin D supplementation, and 88% (168 of 191) were successfully repleted. More than half of the subjects (58%) who were successfully repleted received doses of 2000 IU daily. The mean time to successful repletion was 31 days (standard deviation 8.4 days; range 11–48 days). Conclusion: Supplementation with daily median doses of 2000 IU vitamin D successfully repleted 88% of Korean postmenopausalwomen with osteoporosis within 48 days to a serum vitamin D level of 50 nmol/L.
참고문헌 (11)
- Watts NB, "American Association of Clinical Endocrinologists Medical Guidelines for Clinical Practice for the diagnosis and treatment of postmenopausal osteoporosis", Endocr Pract, 16(Suppl 3), pp.1~37 (2010)
- Prentice RL, "Health risks and benefits from calcium and vitamin D supplementation: Women’s Health Initiative clinical trial and cohort study", Osteoporos Int, 24, pp.567~580 (2013)
- Bischoff-Ferrari HA, "A pooled analysis of vitamin D dose requirements for fracture prevention", N Engl J Med, 367, pp.40~49 (2012)
- 홍희옥, "Effects of calcium intake, milk and dairy product intake, and blood vitamin D level on osteoporosis risk in Korean adults: analysis of the 2008 and 2009 Korea National Health and Nutrition Examination Survey", Nutrition Research and Practice, 7(5), pp.409~417 (2013), 한국영양학회
- Lips P, "The prevalence of vitamin D inadequacy amongst women with osteoporosis: an international epidemiological investigation", J Intern Med, 260, pp.245~254 (2006)
- Choi HS, "Vitamin D insuffciency in Korea--a greater threat to younger generation:the Korea National Health and Nutrition Examination Survey (KNHANES) 2008.", J Clin Endocrinol Metab, 96, pp.643~651 (2011)
- Koh JM, "Effcacy and safety results from a six month double-blind study comparing 60mg denosumab (DMAb) and placebo in Korean postmenopausal women with osteoporosis", J Bone Miner Res, 28(Suppl 1) (2013)
- Pepper KJ, "Evaluation of vitamin D repletion regimens to correct vitamin D status in adults", Endocr Pract, 15, pp.95~103 (2009)
- Vande Griend JP, "Prescription ergocalciferol dosing for vitamin D repletion: a retrospective evaluation", Pharmacotherapy, 32, pp.135~141 (2012)
- Cummings SR, "Denosumab for prevention of fractures in postmenopausal women with osteoporosis", N Engl J Med, 361, pp.756~765 (2009)
- Holick MF, "Vitamin D deficiency", N Engl J Med, 357, pp.266~281 (2007)