Vitamin D Status and Response to Initial Vitamin D Supplementation in Korean Women with Osteoporosis
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Background: The aim of this study is to evaluate whether the optimal vitamin D level isachieved after taking recommended dose in vitamin D deficient patients. Methods: Thiswas a retrospective study. Women (n=52) first diagnosed with osteoporosis were recruit-ed in outpatient clinic. They were recommended to be exposed to sun light for morethan 30 min a day. Subjects were divided into 3 groups according to serum 25-hydroxy-vitamin D3 (25-[OH]D3) status: deficiency (less than 20 ng/mL), insufficiency (20-30 ng/mL) and sufficiency (30 ng/mL or more). Insufficient and sufficient patients received therecommended dose (1,000 IU/day) but deficient patients received recommended ordouble dose (1,800-2,000 IU/day). We compared 25-(OH)D levels at baseline and aftervitamin D supplementation for 3 months. Results: Median (interquartile range) serum25-(OH)D concentration at baseline was 15.10 (13.30-16.97) ng/mL and the proportionof deficient, insufficient and sufficient groups were 69.2%, 23.1%, and 7.7% respectively. The optimal 25-(OH)D level (30 ng/mL or more) was achieved in 83.3% of insufficientpatients with the recommended dose and was did in 55.6% of deficient patients withrecommended dose (P=0.117). However, 88.9% of the deficient patient with doubledose achieved optimal level (P=0.030). Conclusions: About 44% of vitamin D deficientpatients did not attain the optimal level of serum 25-(OH)D despite recommended dailyintake of vitamin D to 1,000 IU in patients with osteoporosis. Follow-up of serum 25-(OH)D levels may be required for vitamin D supplementation in vitamin D deficient patientswith osteoporosis.
Abstract
Background: The aim of this study is to evaluate whether the optimal vitamin D level isachieved after taking recommended dose in vitamin D deficient patients. Methods: Thiswas a retrospective study. Women (n=52) first diagnosed with osteoporosis were recruit-ed in outpatient clinic. They were recommended to be exposed to sun light for morethan 30 min a day. Subjects were divided into 3 groups according to serum 25-hydroxy-vitamin D3 (25-[OH]D3) status: deficiency (less than 20 ng/mL), insufficiency (20-30 ng/mL) and sufficiency (30 ng/mL or more). Insufficient and sufficient patients received therecommended dose (1,000 IU/day) but deficient patients received recommended ordouble dose (1,800-2,000 IU/day). We compared 25-(OH)D levels at baseline and aftervitamin D supplementation for 3 months. Results: Median (interquartile range) serum25-(OH)D concentration at baseline was 15.10 (13.30-16.97) ng/mL and the proportionof deficient, insufficient and sufficient groups were 69.2%, 23.1%, and 7.7% respectively. The optimal 25-(OH)D level (30 ng/mL or more) was achieved in 83.3% of insufficientpatients with the recommended dose and was did in 55.6% of deficient patients withrecommended dose (P=0.117). However, 88.9% of the deficient patient with doubledose achieved optimal level (P=0.030). Conclusions: About 44% of vitamin D deficientpatients did not attain the optimal level of serum 25-(OH)D despite recommended dailyintake of vitamin D to 1,000 IU in patients with osteoporosis. Follow-up of serum 25-(OH)D levels may be required for vitamin D supplementation in vitamin D deficient patientswith osteoporosis.
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