Efficacy of Dual Energy X-ray Absorptiometry for Evaluation of Biomechanical Properties: Bone Mineral Density and Actual Bone Strength
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Introduction: Bone mineral density (BMD) is an important index in diagnosis of osteo-porosis and other metabolic bone diseases, prediction of fractures, and monitoringtreatment. This study was to find a more feasible technique for prediction of osteoporot-ic fracture between dual energy X-ray absorptiometry (DXA) and quantitative computedtomography (QCT) and to reveal the actual change of bone strength when BMD waschanged. Methods: Ten of these 20 specimens were used as the demineralized groupand the other 10 as the control. Each specimen was immersed in HCl solution at for aperiod of at least 10 minutes, up to 100 minutes, at an interval of 10 minutes for differ-ent levels of demineralization. BMD was measured using DXA and QCT. Uniaxial com-pression tests were conducted to mea sure biomechanical parameters. Pearson correla-tion analysis was used respectively be tween BMD and biomechanical parameters andbetween DXA and QCT. Results: Elastic modulus (r=0.87) and yield stress (r=0.84)showed a statistically significant correlation with DXA BMD. Through correlation analysiswith QCT BMD and elastic modulus, correlation coef ficient showed hemi-vertebra(r=0.80) and trabecular (r=0.68). In yield stress, there was a statistically significant cor-relation in hemi-vertebra (r=0.87) and trabecular bone (r=0.84). Conclusion: DXA is acurrent standard technique not only for diagnosis of osteoporosis but also for predictionof fracture risk compared to QCT. Actual decrease of bone strength was much greaterthan that of BMD by both DXA and QCT.
Abstract
Introduction: Bone mineral density (BMD) is an important index in diagnosis of osteo-porosis and other metabolic bone diseases, prediction of fractures, and monitoringtreatment. This study was to find a more feasible technique for prediction of osteoporot-ic fracture between dual energy X-ray absorptiometry (DXA) and quantitative computedtomography (QCT) and to reveal the actual change of bone strength when BMD waschanged. Methods: Ten of these 20 specimens were used as the demineralized groupand the other 10 as the control. Each specimen was immersed in HCl solution at for aperiod of at least 10 minutes, up to 100 minutes, at an interval of 10 minutes for differ-ent levels of demineralization. BMD was measured using DXA and QCT. Uniaxial com-pression tests were conducted to mea sure biomechanical parameters. Pearson correla-tion analysis was used respectively be tween BMD and biomechanical parameters andbetween DXA and QCT. Results: Elastic modulus (r=0.87) and yield stress (r=0.84)showed a statistically significant correlation with DXA BMD. Through correlation analysiswith QCT BMD and elastic modulus, correlation coef ficient showed hemi-vertebra(r=0.80) and trabecular (r=0.68). In yield stress, there was a statistically significant cor-relation in hemi-vertebra (r=0.87) and trabecular bone (r=0.84). Conclusion: DXA is acurrent standard technique not only for diagnosis of osteoporosis but also for predictionof fracture risk compared to QCT. Actual decrease of bone strength was much greaterthan that of BMD by both DXA and QCT.
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