용암해수와 홍삼추출물 혼합시료의 항염 및 항자극 효능 연구
Studies on Anti-inflammatory and Anti-irritation Effects of the Mixture of Jeju Lava Seawater and Red Ginseng Extract
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In recent days, there is a growing attention toward well-being, health, and functional cosmetics. In this regard, the Jeju lava seawater and red ginseng have been widely applied as food and cosmetic in many industrial products. In the current research, a mixture of Jeju lava seawater and red ginseng extract has been confirmed to have an appropriate concentration for processing RAW264.7, HaCaT and THP-1 cells, 0.625% for RAW264.7, 3.125% for HaCaT. For THP-1 cell, the mixed sample at the concentration of less than 10% did not affect the cell viability. When the test was conducted based on this, the mixture of Jeju lava seawater and red ginseng extract significantly inhibited the expression of NO increase by LPS, and IL-8 increase by TNF-α and UVA. IL-8, IL-6 induced by UVB also showed significant inhibitory efficacy in a concentration-dependent manner. The result of suppression of the expressions of CD54 and CD86 cell surface proteins involved in the stimulation response in immune cells induced by stimulation with the chemical sensitizer DNCB, which is the cause of the immune response, suggest that the mixed sample is effective in anti-stimulation. This result shows that the mixture of Jeju lava seawater and red ginseng extract is a potential substance for skin inflammation relief and anti-irritation.
Abstract
In recent days, there is a growing attention toward well-being, health, and functional cosmetics. In this regard, the Jeju lava seawater and red ginseng have been widely applied as food and cosmetic in many industrial products. In the current research, a mixture of Jeju lava seawater and red ginseng extract has been confirmed to have an appropriate concentration for processing RAW264.7, HaCaT and THP-1 cells, 0.625% for RAW264.7, 3.125% for HaCaT. For THP-1 cell, the mixed sample at the concentration of less than 10% did not affect the cell viability. When the test was conducted based on this, the mixture of Jeju lava seawater and red ginseng extract significantly inhibited the expression of NO increase by LPS, and IL-8 increase by TNF-α and UVA. IL-8, IL-6 induced by UVB also showed significant inhibitory efficacy in a concentration-dependent manner. The result of suppression of the expressions of CD54 and CD86 cell surface proteins involved in the stimulation response in immune cells induced by stimulation with the chemical sensitizer DNCB, which is the cause of the immune response, suggest that the mixed sample is effective in anti-stimulation. This result shows that the mixture of Jeju lava seawater and red ginseng extract is a potential substance for skin inflammation relief and anti-irritation.
참고문헌 (29)
- Kwang-Soo Baek, "In vitro and in vivo anti-inflammatory activities of Korean Red Ginseng-derived components", Journal of Ginseng Research, 40(4), pp.437~444 (2016), 고려인삼학회
- M. Denda, "Some magnesium salts and a mixture of magnesium and calcium salts accelerate skin barrier recovery", Archives of Dermatological Research, 291(10), pp.560~563 (1999), Springer Science and Business Media LLC[DOI]
- Anna B. Fishbein, "Asian Ginseng Enhances the Anti-proliferative Effect of 5-Fluorouracil on Human Colorectal Cancer: Comparison between White and Red Ginseng", Archives of Pharmacal Research, 32(4), pp.505~513 (2009), 대한약학회[DOI]
- Cem Gabay, "Interleukin-6 and chronic inflammation", Arthritis Research & Therapy, 8(Suppl 2), pp.S3~ (2006), Springer Science and Business Media LLC[DOI]
- 홍창의, "Anti-inflammatory and Anti-oxidative Effects of Korean Red Ginseng Extract in Human Keratinocytes", Immune Network, 11(1), pp.42~49 (2011), 대한면역학회[DOI]
- 임도연, "화피의 휘발성 향기성분 조성과 주요성분인 Benzaldehyde의 생리활성", 아시안뷰티화장품학술지, 12(2), pp.155~162 (2014), 한국피부과학연구원
- 장영아, "홍삼추출물이 LPS로 유도된 RAW 264.7 cell의 염증반응에 미치는 효과", 한국응용과학기술학회지, 36(4), pp.1434~1442 (2019), 한국응용과학기술학회[DOI]
- Hyun-Joo Jung, "Enhancement of anti-inflammatory and antinociceptive actions of red ginseng extract by fermentation", Journal of Pharmacy and Pharmacology, 64(5), pp.756~762 (2012), Oxford University Press (OUP)[DOI]
- Hyunae Kim, "Stimulatory Effect of Dietary Red Ginseng on Epidermal Hydration and Ceramide Levels in Ultraviolet-Irradiated Hairless Mice", Journal of Medicinal Food, 12(4), pp.746~754 (2009), 한국식품영양과학회[DOI]
- Junoh Kim, "Inhibition effect of Gynura procumbens extract on UV-B-induced matrix-metalloproteinase expression in human dermal fibroblasts", Journal of Ethnopharmacology, 137(1), pp.427~433 (2011), Elsevier BV[DOI]
- Hyun Joo Lee, "Korean red ginseng (Panax ginseng) improves insulin sensitivity and attenuates the development of diabetes in Otsuka Long-Evans Tokushima fatty rats", Metabolism, 58(8), pp.1170~1177 (2009), Elsevier BV[DOI]
- 이해진, "加味消風散이 염증 및 아토피피부염 동물병태에 미치는 영향", 동의생리병리학회지, 28(2), pp.146~153 (2014), 한의병리학회
- 이종원, "홍삼에 함유된 갈변물질 및 산성다당체에 대한 연구현황", Journal of Ginseng Research, 30(1), pp.41~48 (2006), 고려인삼학회
- Lee JW, "Function of the water soluble browning reaction products isolated from Korean red ginseng 2. linoleic acid, ox-brain autoxidant and Fe2+ ADP", NAD system, 2000, pp.24, 35~40
- 이승홍, "Antioxidant and Anti-inflammatory Activities of the Ethanolic Extract of Fermented Red Ginseng Marc", Food Science and Biotechnology, 24(2), pp.651~657 (2015), 한국식품과학회[DOI]
- 오성화, "붉은덕다리버섯 균사체로 발효한 홍삼 배양액의 cell migration 및 항염 효능에 관한 연구", 대한화장품학회지, 40(3), pp.297~305 (2014), 사단법인 대한화장품학회[DOI]
- 박혜진, "홍삼과 발효홍삼의 항염증 작용 및 항알러지 효과 비교", 한국자원식물학회지, 23(5), pp.415~422 (2010), 한국자원식물학회
- Park JD, "Recent studies on the chemical constituents of Korean ginseng (panax ginseng C.A. Meyer)", J Ginseng Res, 20, pp.389~415 (1996)
- Ehrhardt Proksch, "Bathing in a magnesium-rich Dead Sea salt solution improves skin barrier function, enhances skin hydration, and reduces inflammation in atopic dry skin", International Journal of Dermatology, 44(2), pp.151~157 (2005), Wiley[DOI]
- Saba E, "Rhee MH : Anti-inflammatory activity of Rg3-enriched Korean red ginseng extract in murine model of sepsis", Evid Based Complementary Altern Med (2018)[DOI]
- 신지수, "Lipopolysaccharide로 유도된 RAW264.7 세포에서 MAPK에 의한 홍삼추출물의 항염증 효과", 동의생리병리학회지, 26(3), pp.293~300 (2012), 한의병리학회[DOI]
- 신용서, "인삼과 팽화홍삼의 Ginsenoside 함량 및 항염효과 비교", 한국식품조리과학회지, 26(4), pp.475~480 (2010), 한국식품조리과학회
- 손명수, "홍삼에서 추출한 오일의 항산화 및 보습활성", 아시안뷰티화장품학술지, 11(3), pp.489~494 (2013), 한국피부과학연구원
- Harvinder S. Talwar, "Reduced Type I and Type III Procollagens in Photodamaged Adult Human Skin", Journal of Investigative Dermatology, 105(2), pp.285~290 (1995), Elsevier BV[DOI]
- Jos J. van Triel, "Allergic inflammation in the upper respiratory tract of the rat upon repeated inhalation exposure to the contact allergen dinitrochlorobenzene (DNCB)", Toxicology, 269(1), pp.73~80 (2010), Elsevier BV[DOI]
- Le Ba Vinh, "Two new dammarane-type triterpene saponins from Korean red ginseng and their anti-inflammatory effects", Bioorganic & Medicinal Chemistry Letters, 27(23), pp.5149~5153 (2017), Elsevier BV[DOI]
- Vladimir Vuksan, "Korean red ginseng (Panax ginseng) improves glucose and insulin regulation in well-controlled, type 2 diabetes: Results of a randomized, double-blind, placebo-controlled study of efficacy and safety", Nutrition, Metabolism and Cardiovascular Diseases, 18(1), pp.46~56 (2008), Elsevier BV[DOI]
- Meinhard Wlaschek, "Solar UV irradiation and dermal photoaging", Journal of Photochemistry and Photobiology B: Biology, 63(1-3), pp.41~51 (2001), Elsevier BV[DOI]
- Taddessee Yayeh, "Korean Red Ginseng Saponin Fraction Downregulates Proinfl ammatory Mediators in LPS Stimulated RAW264.7 Cells and Protects Mice against Endotoxic Shock", Journal of Ginseng Research, 36(3), pp.263~269 (2012), 고려인삼학회