대추씨 추출물의 UVB에 의한 피부 광노화 억제 효과
Inhibitory Effect of Jujube Seed Extract on Ultraviolet B-induced Photoaging
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초록
Ultraviolet (UV) is a major factor in photoaging of skin, and an abnormal reaction of the keratin cycle from the base layer of the skin to the keratin layer, which reduces the amount of moisture in the epidermis, reducing the thickness of collagen fibers in the dermis, and breaking the binding of elastic fibers, occurs in photo-aging skin. This study was conducted in order to examine the effects of expression of MMP-2, 9, and Type I Procollagen induced by antioxidant and UVB of jujube seed extract. The 60% ethanol extract of jujube seeds showed significant radical scavenging activity using the DPPH method and the ABTS method, and in assessment of hydrogen peroxide radical scavenging activity, and minimal SOD-like activity effect was observed. Weak activity of 30.76% at 1,000 ug/mL from collagenase inhibitory activity was detected for 60% ethanol extract of jujube seeds. These findings demonstrated the protective effect of J60 in response to UVB-induced aging in human fibroblast cells through regulation of the type-1 procollagen, MMP-9.
Abstract
Ultraviolet (UV) is a major factor in photoaging of skin, and an abnormal reaction of the keratin cycle from the base layer of the skin to the keratin layer, which reduces the amount of moisture in the epidermis, reducing the thickness of collagen fibers in the dermis, and breaking the binding of elastic fibers, occurs in photo-aging skin. This study was conducted in order to examine the effects of expression of MMP-2, 9, and Type I Procollagen induced by antioxidant and UVB of jujube seed extract. The 60% ethanol extract of jujube seeds showed significant radical scavenging activity using the DPPH method and the ABTS method, and in assessment of hydrogen peroxide radical scavenging activity, and minimal SOD-like activity effect was observed. Weak activity of 30.76% at 1,000 ug/mL from collagenase inhibitory activity was detected for 60% ethanol extract of jujube seeds. These findings demonstrated the protective effect of J60 in response to UVB-induced aging in human fibroblast cells through regulation of the type-1 procollagen, MMP-9.
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