건지황 추출물의 피부노화억제 효능에 대한 연구
Effect of Dryed Rehmanniae Radix Root Extract for Anti-skin Aging.
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In this study, the antioxidant, wrinkle suppression effect of extracts from Rehmanniae radix root(RRR) were investigated. DPPH radical scavenging activities significantly increased in a RRR extract(RRRE) concentration-dependent manner. The measured total polyphenol content of RRRE was 18.8±2.9mg/g. Matrix-metalloproteinase (MMP)-1,3 and 9 expressions were induced by UV-B irradiation in human primary dermal fibroblasts. The RRRE inhibited MMP-1,3(p<0.001) and 9(p<0.01) expression significantly compare to negative control group. Type 1 procollagen and TIMP-1 expression increased significantly by RRRE in wrinkle suppression efficacy test using CCD-986SK, human originated fibroblast. The RRRE was verified to have effects in antioxidant and wrinkle suppression, it could be developed as the possible excellent cosmeceutical products in anti-aging and antioxidants.
Abstract
In this study, the antioxidant, wrinkle suppression effect of extracts from Rehmanniae radix root(RRR) were investigated. DPPH radical scavenging activities significantly increased in a RRR extract(RRRE) concentration-dependent manner. The measured total polyphenol content of RRRE was 18.8±2.9mg/g. Matrix-metalloproteinase (MMP)-1,3 and 9 expressions were induced by UV-B irradiation in human primary dermal fibroblasts. The RRRE inhibited MMP-1,3(p<0.001) and 9(p<0.01) expression significantly compare to negative control group. Type 1 procollagen and TIMP-1 expression increased significantly by RRRE in wrinkle suppression efficacy test using CCD-986SK, human originated fibroblast. The RRRE was verified to have effects in antioxidant and wrinkle suppression, it could be developed as the possible excellent cosmeceutical products in anti-aging and antioxidants.
참고문헌 (13)
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