상처 치료를 위한 천연물 유래 하이드로콜로이드 밴드 개발
Development of a Natural Product-derived Hydrocolloid Band for Wound Healing
1
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Hydrocolloid bands, which enclose a wound in a gel form, can prevent fading and protect the wound from the external environment; however there are also problems associated with their use, such as skin irritation and bacterial growth. In this study, a liquid-type hydrocolloid band that can provide an antibacterial effect while minimizing skin irritation was developed and its functionality was confirmed. The mixing ratio was optimized by mixing natural product-derived pectin LM and agar in order to obtain a gelation suitable for use as a component of a wound healing band, with optimization of conditions for formation of a film without including volatile components. The result of measuring the moisturizing power with the optimized natural product-derived composition showed that when D-panthenol and hyaluronic acid were mixed in an 8:2 ratio, an increase in the moisture content of the skin was observed even after 4 hours, so that an excellent moisturizing effect was confirmed. In addition, an antibacterial effect against Staphylococcus aureus at 3.4% of bee venom and 0.7% of lavender oil was confirmed, demonstrating the suitability of the natural product-derived hydrocolloid band as a material for application in wound healing. Therefore, application of this natural products-derived hydrocolloid band to various wound treatments can result in eradication of the cause of chemical allergic reactions, by providing an excellent moisturizing capacity for prevention of wound drying, as well as a powerful antibacterial effect.
Abstract
Hydrocolloid bands, which enclose a wound in a gel form, can prevent fading and protect the wound from the external environment; however there are also problems associated with their use, such as skin irritation and bacterial growth. In this study, a liquid-type hydrocolloid band that can provide an antibacterial effect while minimizing skin irritation was developed and its functionality was confirmed. The mixing ratio was optimized by mixing natural product-derived pectin LM and agar in order to obtain a gelation suitable for use as a component of a wound healing band, with optimization of conditions for formation of a film without including volatile components. The result of measuring the moisturizing power with the optimized natural product-derived composition showed that when D-panthenol and hyaluronic acid were mixed in an 8:2 ratio, an increase in the moisture content of the skin was observed even after 4 hours, so that an excellent moisturizing effect was confirmed. In addition, an antibacterial effect against Staphylococcus aureus at 3.4% of bee venom and 0.7% of lavender oil was confirmed, demonstrating the suitability of the natural product-derived hydrocolloid band as a material for application in wound healing. Therefore, application of this natural products-derived hydrocolloid band to various wound treatments can result in eradication of the cause of chemical allergic reactions, by providing an excellent moisturizing capacity for prevention of wound drying, as well as a powerful antibacterial effect.
참고문헌 (26)
- 안원술, "PFA 및 MWCNT의 기핵효과에 의한 경질 폴리우레탄 폼의 물성 변화에 대한 연구", 한국산학기술학회논문지, 16(4), pp.2945~2950 (2015), 한국산학기술학회[DOI]
- Ahn YH, "R&d strategic planning report about a liquid wound dressing containing natural extracts", Master, pp.2015
- 백지훈, "피부수분 측정법", 아시안뷰티화장품학술지, 4(1), pp.147~154 (2006), 한국피부과학연구원
- 지원재, "한천분해 미생물 Vibrio sp. GNUM08123의 동정 및 agarase 생산의 발효적 특성", 한국미생물·생명공학회지, 45(3), pp.243~249 (2017), 한국미생물·생명공학회
- 한현호, "만성창상의 치료에 쓰이는 치료제재", 대한의사협회지, 58(9), pp.809~813 (2015), 대한의사협회[DOI]
- Han NG, "Material for wound healing", Fiber Technol Ind, 8, pp.172~182 (2004)
- 한승규, "우리나라의 최신 창상피복법", 대한의사협회지, 54(6), pp.594~603 (2011), 대한의사협회
- 한상미, "구강질환 원인균에 대한 정제봉독의 항균효과", 생약학회지, 47(1), pp.43~48 (2016), 한국생약학회
- 한상미, "천연항생제로서 봉독의 기원 및 지표성분 설정", 한국가축위생학회지, 37(2), pp.123~129 (2014), 한국동물위생학회
- Hwang JG, "Review : structure and function of pectin polysaccharide", AgroBiotech, 3, pp.85~96 (1996)
- 진시형, "미세유체 장치에서 부분젤화법을 이용한 단분산성 펙틴 하이드로젤 미세섬유의 제조", Clean Technology, 23(3), pp.270~278 (2017), 한국청정기술학회
- Kang HI, "Fluid properties and agar solution from cheju seaweed, gelidium amansii", Korean J Fish Aquat Sci, 29, pp.716~721 (1996)
- 강진선, "피부투과 기능성 펩타이드를 이용한 경피투과성 상피세포성장인자의 개발", 대한화장품학회지, 45(2), pp.175~184 (2019), 사단법인 대한화장품학회[DOI]
- 김채연, "미세유체 장치에서 수거 방법에 따른 펙틴 하이드로겔 입자의 특성 비교", Korean Chemical Engineering Research(HWAHAK KONGHAK), 53(6), pp.740~745 (2015), 한국화학공학회
- Kim HG, "Physicochemical and rheological properties of agar by physical treatment", Korean J Food & Nutr, 10, pp.228~233 (1997)
- 김희진, "천연 고분자 한천 하이드로젤의 접목도에 따른 소수성 제어 및 특성 분석", 폴리머, 40(2), pp.321~327 (2016), 한국고분자학회[DOI]
- 김장순, "아로마테라피가 스트레스 관련 호르몬에 미치는 영향", 한국미용학회지, 15(4), pp.1452~1462 (2009), 한국미용학회
- Kim SY, "Effect of pH and agar concentration of medium on acid production of S. mutans", J Wonkwang Dent Res Ins, 2, pp.151~161 (1992)
- 권오형, "합성고무와 카르복시메틸셀룰로오스(CMC) 나트륨을 이용한 하이드로콜로이드형 창상치료재의 제조 및 평가", 폴리머, 40(1), pp.101~108 (2016), 한국고분자학회[DOI]
- 이희우, "사람의 피부상피세포에서 황색포도상구균의 독소인자인 Staphylococcal Protein A의 염증반응 촉진효과", 미생물학회지, 47(4), pp.348~355 (2011), 한국미생물학회
- 민성준, "FGF가 고정화된 UV경화형 히알루론산 유도체를 이용한 Injectable한 수화젤의 제조", 폴리머, 44(4), pp.451~458 (2020), 한국고분자학회[DOI]
- Park GS, "The effects of addition of agar on the texture characteristics of peach jelly", Korean J Food & Nutr, 11, pp.61~67 (1998)
- 신유현, "천연 에센셜 오일의 주요 구성물질 분석과 항산화 및 항균 효과에 관한 연구", 생명과학회지, 22(10), pp.1344~1351 (2012), 한국생명과학회[DOI]
- Son HH, "Analyzation of disinfecting flesh wound using atmospheric pressure plasma", J Ind Eng Chem, 2011, pp.286~286 (2011)
- Song JC, "Literature review of wound healing", J Korean Med Rehabil, 11, pp.1~15 (2001)
- Yang BS, "Biological mechanism to control skin regeneration and scar formation", J Wound Manag Res, 4, pp.74~83 (2008)