골격근 기억기전 연구동향 분석
Skeletal muscle memory mechanism: From past to future
1
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
전통적인 근핵도메인이론에 의하면 골격근의 부피와 근핵의 수는 정적상관관계에 있으며 두 변수 간 비율은 항상 일정하게 유지되는 것으로 알려져 있다. 하지만 골격근섬유 분석 장비의 비약적 발전으로 인해 이 전통적인 이론이 강하게 도전받고 있는 실정이다. 이와 관련하여 부상하고 있는 신생이론인 골격근 기억기전은 근감소 시, 근핵의 수는 장기간 소멸되지 않고 유지되어 추후 운동자극에 신속하고 효과적인 반응을 유도하는 세포학적 기전을 제공할 수 있음을 주장하고 있다. 최근 이 신생이론인 골격근 기억기전은 대다수 동물모델을 이용한 실험으로 증명되고 있으나 아직 인간 대상연구 및 적용의 제한점으로 인해 운동과학자들의 컨센서스에 도달하지는 못한 상황이다. 따라서 본 연구에서 현재까지 진행되어 온 골격근 기억기전의 연구동향을 분석하여 관련 실험의 제한점 및 가능성을 탐색하고 미래 연구방향을 제언하고자 한다.
Abstract
Based on the paradigm of the myonuclear domain theory, it is considered that a positive relationship exists between myonuclear number and skeletal muscle size. However, a series of recent experiments with advanced microscopy suggest that hypertrophy-induced myonuclei are not lost for a long period under atrophic condition, implying that myouclei that are added to muscle fiber may play an important role in muscle memory mechanism. However, there is still controversy as to whether this new theory should be accepted as a general consensus in the field of exercise science communities. Therefore, the potential and limitation of the theory will be widely discussed in the review. And future research directions as to skeletal muscle memory mechanism will be suggested.
참고문헌 (26)
- Allbrook D., "Population of muscle satellite cells in relation to age and mitotic activity", Pathology, 3(3), pp.223~243 (1971)
- Bruusgaard J., "No change in myonuclear number during muscle unloading and reloading", Journal of Applied Physiology, 113(2), pp.290~296 (2012)
- Bruusgaard J., "In vivo time-lapse microscopy reveals no loss of murine myonuclei during weeks of muscle atrophy", Journal of Clinical Investigation, 118(4), pp.1450~1457 (2008)
- Bruusgaard J., "Specific labelling of myonuclei by an antibody against pericentriolar material 1 on skeletal muscle tissue sections", Acta Physiologica, 223(4), pp.1~9 (2018)
- Bruusgaard J., "Myonuclei acquired by overload exercise precede hypertrophy and are not lost on detraining", Proceedings of the National Academy of Sciences, 107(34), pp.15111~15116 (2010)
- Bruusgaard J., "Distribution of myonuclei and microtubules in live muscle fibers of young, middle-aged, and old mice", Journal of Applied Physiology, 100(6), pp.2024~2030 (2006)
- Cheek D., "The control of cell mass and replication. The DNA unit–a personal 20-year study", Early Human Development, 12(3), pp.211~239 (1985)
- Chen B., "The role of satellite and other functional cell types in muscle repair and regeneration", Journal of Muscle Research and Cell Motility, 40(1), pp.1~8 (2019)
- Demetrius L., "Of mice and men. When it comes to studying ageing and the means to slow it down, mice are not just small humans", EMBO Reports, 2005(6), pp.S39~44 (2005)
- Dumont N., "Satellite Cells and Skeletal Muscle Regeneration", Comprehensive Physiology, 5(3), pp.1027~1059 (2015)
- Egner I., "A cellular memory mechanism aids overload hypertrophy in muscle long after an episodic exposure to anabolic steroids", Journal of Physiology, 591(24), pp.6221~6230 (2013)
- Giordani L., "Satellite Cell Self-Renewal", Current Topics in Developmental Biology, 2018(126), pp.177~203 (2018)
- Gundersen K., "Muscle memory and a new cellular model for muscle atrophy and hypertrophy", Journal of Experimental Biology, 219(2), pp.235~242 (2016)
- Hall Z., "Nuclear domains in muscle cells", Cell, 59(5), pp.771~772 (1989)
- Hellmuth A., "Muscle satellite cell numbers during the postnatal period", Journal of Anatomy, 110, pp.503~ (1971)
- Holwerda A., "Protein supplementation after exercise and before sleep does not further augment muscle mass and strength gains during resistance exercise training in active older men", The Journal of Nutrition, 148(11), pp.1723~1732 (2018)
- Lee H., "A cellular mechanism of muscle memory facilitates mitochondrial remodelling following resistance training", Journal of Physiology, 596(18), pp.4413~4426 (2018)
- Moro T., "Resistance exercise training promotes fiber type-specific myonuclear adaptations in older adults", Journal of Applied Physiology, 128(4), pp.795~804 (2020)
- Morgan J., "Muscle satellite cells", The International Journal of Biochemistry & Cell Biology, 35(8), pp.1151~1156 (2003)
- Pavlath G., "Localization of muscle gene products in nuclear domains", Nature, 337(6207), pp.570~573 (1989)
- Seaborne R., "Human skeletal muscle possesses an epigenetic memory of hypertrophy", Scientific Reports, 8(1), pp.1898~ (2018)
- Schiaffino S., "Mechanisms regulating skeletal muscle growth and atrophy", The FEBS Journal, 280(17), pp.4294~4314 (2013)
- Snijders T., "Changes in myonuclear domain size do not precede muscle hypertrophy during prolonged resistance-type exercise training", Acta Physiologica, 216(2), pp.231~239 (2016)
- Verdijk L., "Protein supplementation before and after exercise does not further augment skeletal muscle hypertrophy after resistance training in elderly men", The American Journal of Clinical Nutrition, 89(2), pp.608~616 (2009)
- Winje I., "Specific labelling of myonuclei by an antibody against pericentriolar material 1 on skeletal muscle tissue sections", Acta Physiologica, 223(4), pp.e13034~ (2018)
- Yan Z., "Exercise training-induced regulation of mitochondrial quality", Exercise and Sport Sciences Reviews, 40(3), pp.159~164 (2012)