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경남 일부지역 고혈압 전단계와 고혈압 환자의 신체계측 및 생화학적 특성에 관한 연구

A Study on the Anthropometric and Biochemical Characteristics of Pre-hypertensive and Hypertensive Patients in Gyeongnam Area

김성희|최선영|서인경
농업생명과학연구원 (Institute of Agriculture & Life Science, Gyeongsang National University)|2014|농업생명과학연구 (Journal of Agriculture & Life Science)|제48권 제1호|pp. 127-138|DOI http://dx.doi.org/10.14397/jals.2014.48.1.127

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키워드

Ascorbic acid동맥경화지수콜레스테롤Atherogenic indexCholesterolAldosterone아스코르브산아포지단백알도스테론Apolipoprotein

초록

본 연구는 40-60세 남성들 119명을 대상으로 혈압과 체위지수 및 생화학적 지수와의 관련성을 조사․분석하였다. 평균 혈압은 정상혈압군 104.5 ± 5.9/67.3 ± 5.0 mmHg, 전단계고혈압군 125.2 ± 5.1/77.5 ± 7.1 mmHg, 고혈압군 143.5 ± 8.9/90.2 ± 7.3 mmHg로 나타났다. 체질량지수 및 허리-엉덩이둘레비는 고혈압군이 정상혈압군 및 전단계고혈압군보다 높았다. 혈색소와 혈청 알부민, 포도당, 알라닌트랜스아미나제, 알도스테론 농도는 고혈압군이 정상혈압군 및 전단계고혈압군보다 높았다. 혈청 총콜레스테롤, LDL-콜레스테롤, 아포지단백 B 농도 및 동맥경화지수는 전단계고혈압군 및 고혈압군이 정상혈압군보다 높았다. 혈압이 높은 군일수록 혈청 중성지질 농도는 높은 반면 혈장 아스코르브산의 농도는 낮았다. 전단계고혈압군인 경우에 체질량지수는 아포지단백 A1 및 아스코르브산 농도와 음의 상관성을 나타내었고, 고혈압군인 경우에 체질량지수는 중성지질 농도와, 허리-엉덩이둘레비는 총콜레스테롤 및 LDL-콜레스테롤 농도와 각각 양의 상관성을 나타내었다. 아스코르브산 농도는 정상혈압군과 고혈압군에서 HDL-콜레스테롤 및 아포지단백 A1 농도와는 양의 상관성을 나타낸 반면 동맥경화지수와는 음의 상관성을 나타내었다. 이들 결과로 미루어 고혈압을 예방하기 위해서는 이상적인 체중 유지와 더불어 혈청 지질 및 나트륨 농도를 저하시키고 혈장 아스코르브산 농도를 상승시키는 것이 필요할 것으로 사료된다.

Abstract

This study was undertaken to examine relationships among blood pressure and anthropometric, and biochemical values in 119 adult males aged 40-60 years. The subjects were classified into three groups of normotensive, pre-hypertensive and hypertensive according to the Joint National Committee(JNC)-7 criteria. The mean blood pressure were 104.5 ± 5.9/67.3 ± 5.0 mmHg, 125.2 ± 5.1/77.5 ± 7.1 mmHg and 143.5 ± 8.9/90.2 ± 7.3 mmHg among normotensive group, pre-hypertensive group and hypertensive group, respectively. The body mass index(BMI) and waist-hip ratio(WHR) were significantly higher in hypertensive group than normotensive and pre-hypertensive groups. The levels of hemoglobin, and serum albumin, glucose, alanine transferase(ALT), aldosterone were significantly higher in hypertensive group than normotensive and pre- hypertensive groups. The serum levels of total cholesterol, LDL-cholesterol and apolipoprotein B(Apo B), Na and atherogenic index(AI) were significantly higher in pre-hypertensive and hypertensive groups than normotensive group. The serum triglyceride(TG) level was significantly higher and the plasma ascorbic acid(AA) level was significantly lower, according to the blood pressure. In the normotensive group, BMI and WHR were positively correlated with serum TG, total cholesterol, LDL-cholesterol and Apo B levels, Apo B/Apo A1 and AI. In the pre-hypertensive group, BMI was negatively correlated with serum Apo A1 and plasma AA levels. In the hypertensive group, BMI was positively correlated with serum TG level, and WHR was positively correlated with serum total cholesterol and LDL-cholesterol levels. The AA level was positively correlated with HDL-cholesterol and Apo A1 levels, and negatively correlated with Apo B/Apo A1 and AI in the normotensive and hypertensive groups. These results suggest that maintaining ideal weight, and decreasing serum lipid and Na levels, and increasing plasma AA level in order to prevent hypertension are crucial.

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