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일반인, 만성 간질환, 혈액투석 및 수혈 받은 환자에서의 TT virus(TTV) 감염

TT Virus (TTV) Infection in General Populations, Patients with Chronic Liver Diseases, Patients on Hemodialysis, and Transfused Patients

정규영|이난영|이원길|허운보
대한임상미생물학회 (Korean Society of Clinical Microbiology)|2006.04|Annals of Clinical Microbiology|제9권 제1호|pp. 7-12

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초록

배경：TT virus (TTV)는 1997년 일본에서 수혈로 인하여 발생한 원인불명의 간염 환자에서 최초로 분리되어 간염의 새로운 원인으로 주목받았으나 그 후 환자뿐만이 아니라 건강인에서도 발견되어 간질환에서의 병인론적 역할에 대하여 논란이 일고 있다. 저자들은 TTV 유병률을 조사하고 간에 병변을 유발하는지의 여부를 알기 위하여 일반인, 만성 간질환, 혈액투석 및 수혈 받은 환자에 대하여 TTV DNA의 출현빈도를 조사하였다. 방법：대조군으로 일반인 60예, 만성 간질환 환자 77예, 혈액투석 환자 44예 및 수혈 받은 환자 65 예를 대상으로 혈청을 얻었다. TTV DNA는 이중 중합효소 연쇄반응으로 검출하였으며, 이외에도 알라닌 아미노전이효소(ALT), 아스퍼테이트 아미노전이효소(AST)와 B형 간염 표면항원(HBs Ag)을 검사하였다. 결과：TTV DNA는 일반인 41.7%, 만성 간질환 환자 51.9%, 혈액투석 환자 68.2% 및 수혈 받은 환자의 61.5%에서 각각 검출되었고, 각 군에서 TTV DNA 양성과 음성 예 사이에 AST, ALT 및 HBsAg 검사 결과의 의미 있는 차이를 발견할 수 없었다. 결론：만성 간질환 환자의 TTV 감염률이 일반인과 차이가 없어 TTV 감염과 간질환과는 관련성이 없는 것으로 생각된다. 또한 TTV 감염은 비정상 간기능 검사 소견이나 HBsAg 양성률과도 상관관계가 없었다

Abstract

Background: TT virus (TTV), isolated initially from a Japanese patient with posttransfusion hepatitis of unknown etiology, was suggested to be a new causative agent of hepatitis. However, it has been found to infect both healthy and diseased individuals and numerous studies have raised questions about its pathogenic role in hepatitis. In order to study its prevalence and clinical impact on hepatitis, we assessed the frequency of TTV DNA. Methods: Serum samples were obtained from 60 cases of the controls, 77 cases of chronic liver diseases, 44 cases of hemodialyzed patients, and 65 cases of transfused patients. TTV DNA was detected using nested polymerase chain reaction and alanine aminotransferase (ALT), aspartate aminotransferase (AST), and hepatitis B surface antigen (HBsAg) were measured. Results: TTV DNA was detected in 41.7% of the controls, 51.9% of patients with chronic liver diseases, 68.2% of hemodialyzed patients and 61.5% of transfused patients. Comparison between patients with or without TTV revealed no significant differences in AST, ALT, and HBsAg test results. Conclusion: The prevalance of TTV infection in patients with chronic liver diseases was similar to that in the controls. TTV infection was not related to abnormal liver function findings and HBsAg positivity. We found no relationship between TTV infection and chronic liver diseases.

참고문헌 (26)

  1. "A novel DNA virus (TTV) associated with elevated transaminase levels in posttransfusion hepatitis of unknown etiology.", 241, pp.92~97 (1997)
  2. "Molecular properties, biology, and clinical implications of TT virus, a recently identified widespread infectious agent of humans.", 14, pp.98~113 (2001)
  3. "Molecular and biophysical characterization of TT virus: evidence for a new virus family infecting humans", 96, pp.3177~3182 (1999)
  4. "Molecular cloning and characterization of a novel DNA virus(TTV)associated with posttransfusion hepatitis of unknown etiology", 10, pp.1~16 (1998)
  5. "The entire sequence of a TT virus isolate from the United States(TUS01)comparison with reported isolates and phylogenetic analysis", 259, pp.437~448 (1999)
  6. "Characterization of a highly divergent TT virus genome", 81, pp.2273~2279 (2000)
  7. "Identification of a novel GC-rich 113-nucleotide region to complete the circular,single-stranded DNA genome of TT virus,the first human circovirus", 73, pp.3582~3586 (1999)
  8. "Quasispecies of TT virus(TTV)with sequence divergence in hypervariable regions of the capsid protein in chronic TTV infection", 73, pp.9604~9608 (1999)
  9. "Presence of a newly described human DNA virus(TTV)in patients with liver disease", 352, pp.195~197 (1998)
  10. "A novel unenveloped DNA virus (TT virus) associated with acute and chronic non-A to G hepatitis", 42, pp.196~204 (1999)
  11. "High prevalence of TT virus infection in Japanese patients with liver diseases and in blood donors", 31, pp.221~227 (1999)
  12. "Prevalence and disease association of TT virus infection in Japanese patients with viral he-patitis", 14, pp.161~170 (1999)
  13. "Effect of TT virus infection on hepatocellular carcinoma development:results of a Euro-Asian survey", 181, pp.1138~1142 (2000)
  14. "Impact of TT virus infection in acute and chronic,viral- and non viral-related liver diseases", 33, pp.121~127 (2000)
  15. "Hepatocellular carcinomas infected with the novel TT DNA virus lack viral integration", 251, pp.339~343 (1998)
  16. "TT virus infection among blood donors and patients with non-B,non-C liver diseases in Korea", 30, pp.389~393 (1999)
  17. "TT virus and hepatitis G virus infections in Korean blood donors and patients with chronic liver disease", 9, pp.741~744 (2003)
  18. "Transfusion-transmitted virus and TTV-like mini virus infection in blood products", 24, pp.250~254 (2004)
  19. "Identification of a new human DNA virus (TTV-like minivirus, TLMV) intermediately related to TT virus and chicken anemia virus", 200, pp.979~993
  20. "Transfusion-transmitted virus infection in Korean patients with acute and chronic liver disease of unknown etiology and healthy control:influence of PCR primers on the detection of transfusion transmitted virus", 41, pp.119~125 (2003)
  21. "TT virus in frequently transfused patients", 106, pp.116~117 (1999)
  22. "Natural history of the TT virus infection through follow-up of TTV DNA-positive multiple-transfused patients", 95, pp.347~351 (1999)
  23. "Improved detection systems for TT virus reveal high prevalence in humans,non-human primates and farm animals", 80, pp.2115~2120 (1999)
  24. "TT virus infection in patients with hepatitis C:frequency,persistence,and sequence heterogeneity", 180, pp.27~34 (1999)
  25. "Influence of primers on the detection of TT virus DNA by polymerase chain reaction", 180, pp.1750~1751 (1999)
  26. "Prevalence and clinical significance of TT virus infection in patients on maintenance hemodialysis", 37, pp.14~20 (2001)

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