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헌혈혈액에서 Transfusion-transmitted virus (TTV)와TTV-like mini virus (TLMV)의 감염

Transfusion-transmitted Virus and TTV-like Mini Virus Infection in Blood Products

한태희|김문정|백인기|정주영|상희경
대한진단검사의학회 (Korean Society For Laboratory Medicine)|2004.08|Annals of Laboratory Medicine|제24권 제4호|pp. 250-254

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초록

배경 : TT virus (TTV)와 TTV-like mini virus (TLMV)는 무외피 단일가닥 DNA 바이러스로 수혈을 통해 전파될 수 있다. 국내에서 헌혈자의 TTV 감염률 조사는 이루어진 적이 있으나 혈액제의 TTV 감염률이 조사된 적은 없으며 특히 TLMV의 헌혈자 감염률은 아직 연구되지 않아 저자들은 혈액제제에서TTV와 TLMV 감염률을 조사하고자 하였다.방법 :전혈, 농축적혈구, 농축혈소판 각 50단위의 혈액백 분절에서 혈장을 채취하여 DNA를 추출한 후 TV에 대한 두 종류의 시발체(A, B)와 TLMV에 대한 종류의 시발체(C)를이용하여 중합효소연쇄반응을 시행하였다. 결과 :TTV DNA가 혈액제제 중 85.3% (128/150)에서 검출되었고 TLMV는 혈액제 중 41.3% (62/150)에서 검출되었다.33.3% (50/150)의 혈액제에서 두 바이러스 모두 검출되었고92.3% (140/150)의 혈액제에서 두 바이러스 중 하나 이상 검출되었다. 결론 : 한국에서 TTV와 TLMV가 혈액제제에서도 높은 비율로 검출되어 혈액제제에 의한 두 바이러스의 감염이 발생할 가능성이 높을 것으로 판단되었다.

Abstract

Background : Transfusion-transmitted virus (TTV) and TTV-like mini virus (TLMV) are small DNA virus with single-stranded, closed circular, antisense genome infecting man. TTV and TLMV are transmissible by transfusion. However there had been a few study about TTV prevalence and no study about prevalence in blood donors in Korea. There has been no study about the TTV and TLMV infection in blood products in Korea. The aim of this study was to gain the prevalence of two viruses in blood products. Methods : A total of 150 plasma samples from blood products (each 50 units of Red blood cell, whole blood, and platelet concentrate) were tested. The samples are obtained from the segments of the blood products. TTV DNA was detected using polymerase chain reaction (PCR) with two sets of primers (A set and B set) and TLMV DNA was detected using nested PCR with primer set C. Results : TTV DNA was detected in 85.3% (128/150) of blood products. TLMV DNA was detected in 41.3% (62/150) of blood products. Either TTV or TLMV was detected in a total of 140 blood products (92.3%) and both TTV and TLMV were detected in 50 products (33.3%). Conclusions : The blood products are frequently infected with TTV and (or) TLMV in Korea and they can be transmissible by blood products with high probability. (Korean J Lab Med 2004; 24: 250-4)

참고문헌 (24)

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관련 논문AI추천

헌혈혈액에서 Transfusion-transmitted Virus 유전자그룹의 분포성희경, 정주영, 한태희대한진단검사의학회 · Annals of Laboratory Medicine2005 · 제25권 제2호한국인 건강 성인과 B형 및 C형 간염 바이러스 감염자에서의 시발체에 따른 TT Virus 양성률강희정, 김재석, 김한성, 송원근, 이규만대한임상미생물학회 · Annals of Clinical Microbiology2007 · 제10권 제1호일반인, 만성 간질환, 혈액투석 및 수혈 받은 환자에서의 TT virus(TTV) 감염이난영, 이원길, 정규영, 허운보대한임상미생물학회 · Annals of Clinical Microbiology2006 · 제9권 제1호Investigation of the Prevalence of Human Parvovirus B19 DNA in Korean Plasmapheresis Donors강재원, 권소영, 오덕자, 이유라, 조남선대한진단검사의학회 · Annals of Laboratory Medicine2010 · 제30권 제1호적혈구 농축제재에서 HBV DNA의 노출정도김정숙, 송달효, 이채훈영남대학교 의과대학 · Journal of Yeungnam Medical Science1995 · 제12권 제2호소아의 Transfusion Transmitted Virus-Like Minivirus 유병률정주영, 한태희대한소아감염학회 · Pediatric Infection and Vaccine2004 · 제11권 제2호

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