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논문

Cytotoxic Anthraquinones and Stilbenes from Reynoutria sachalinensis (Fr. Schm.) Nakai

이영미|송규용|WenYi Jin|배기환|나민균
한국약용작물학회|2005.04|한국약용작물학회지 (KOREAN JOURNAL OF MEDICINAL CROP SCIENCE)|제13권 제2호|pp. 80-84

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참고문헌

키워드

cytotoxicityPolygonaceaeReynoutria sachalinensisanthraquinonesstilbenes

초록

Five known anthraquinones, physcion (1), 1-O-methylemodin (2), emodin (3), physcion-8-O-β.-D-glucopyranoside (5), emodin-8-O-β.-D-glucopyranoside (6) and two known stilbenes, trans-resveratrol (4), trans-resveratrol-3-O-β.-D-glucopyranoside (7) were isolated from MeOH extract of Reynoutria sachalinensis (Polygonaceae). All structures were unambiguously established by 1D and 2D NMR and MS data and the compounds were evaluated for their cytotoxicity against L1210, HL-60, B16F10 tumor cell lines in MTT assay. Among the compounds, trans-resveratrol (4) exhibited significant cytotoxic activity with IC50 values of 9.2, 6.7 and 9.8.㎍/㎖ .ㅤagainst the test cell lines respectively, but compounds 1-3 exhibited the moderate cytotoxic activity.

Abstract

Five known anthraquinones, physcion (1), 1-O-methylemodin (2), emodin (3), physcion-8-O-β.-D-glucopyranoside (5), emodin-8-O-β.-D-glucopyranoside (6) and two known stilbenes, trans-resveratrol (4), trans-resveratrol-3-O-β.-D-glucopyranoside (7) were isolated from MeOH extract of Reynoutria sachalinensis (Polygonaceae). All structures were unambiguously established by 1D and 2D NMR and MS data and the compounds were evaluated for their cytotoxicity against L1210, HL-60, B16F10 tumor cell lines in MTT assay. Among the compounds, trans-resveratrol (4) exhibited significant cytotoxic activity with IC50 values of 9.2, 6.7 and 9.8.㎍/㎖ .ㅤagainst the test cell lines respectively, but compounds 1-3 exhibited the moderate cytotoxic activity.

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