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Physicochemical Characterization and Cytotoxic Screening of Diterpene acid

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The diterpene acid (1) was tested for its growth inhibitory effects against tumor cell lines using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Full assignments of the 1D/2D-NMR data of the compound (1) are reported. These results suggest that the diterpene acid (1) possessed a cytotoxic agent.

Abstract

The diterpene acid (1) was tested for its growth inhibitory effects against tumor cell lines using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Full assignments of the 1D/2D-NMR data of the compound (1) are reported. These results suggest that the diterpene acid (1) possessed a cytotoxic agent.

참고문헌 (6)

  1. "Unpublished res" (1998), Unpublished results
  2. "Diterpenes from Anisotome flexuosa" (1997)
  3. "diterpene skeleton from Anisotome flexuosa", pp.1409~1412 (1999)
  4. "Evaluation of a tetrazolium-based semiautomated colorimetric assay Assessment of chemosensitivity testing", pp.936~942 (1987)
  5. "Rapid colorimetric assays for cellular growth and survival application to proliferation and cytotoxicity assays", immu(l), pp.55~63 (1983)
  6. "Cytotoxicity and antimicrobial activity of plants from New compounds"

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