Cytotoxic Constituents from the Aerial Part of Clematis apiifolia L.
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Three known triterpenoids were isolated from MeOH extract of C. apiifolia (Ranunculaceae). Their structures were identified as oleanolic acid (1), ursolic acid (2), hederagenic acid (3) by comparison of their physicochemical and spectral data with the literature values. Among them, 2 was isolated for the first time from this plant. The isolated compounds were evaluated for their cytotoxicity against L1210, HL-60, SK-OV-3 tumor cell lines. All compounds 1-3 were shown good activities with IC50 values ranging from 7.7 to 25.6㎍/㎖. This result suggests that triterpenoids 1-3 are main cytotoxic principles of this plant.
Abstract
Three known triterpenoids were isolated from MeOH extract of C. apiifolia (Ranunculaceae). Their structureswere identified as oleanolic acid (1), ursolic acid (2), hederagenic acid (3) by comparison of their physicochemical and spectraldata with the literature values. Among them, 2 was isolated for the first time from this plant. The isolated compounds were evaluatedfor their cytotoxicity against L1210, HL-60, SK-OV-3 tumor cell lines. All compounds 1-3 were shown good activities withIC50 values ranging from 7.7 to 25.6㎍/㎖. This result suggests that triterpenoids 1-3 are main cytotoxic principles of this plant.