곰의말채 부위별 추출물의 항암 및 면역증진 효과
Anticancer and Immune-modulatory Activities of Extracts from Various Parts of Cornus macrophylla Wall.
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Anticancer and immuno-modulatory activities of methanol extracts from different parts, bark, wood and leaf, of Cornus macrophylla Wall. were investigated in this study. All extracts at a concentration of 1.0㎎/㎖ showed relativity low cytotoxicities on human normal kidney cell (HEK293) by approximately 25%. Bark extract of C. macrophylla showed the highest anticancer activity on human lung cancer cell line (A549) and human breast cancer cell line (MCF-7) by 57.4% and 58.7%, respectively, at a concentration of 1.0㎎/㎖. All extracts enhanced the growth of human B and T cells, showing 38.7% and 65.9% increase compared to control, respectively, by 5 days incubation with bark extract. The secretions of interleukin 6 (IL6) and tumor necrosis factor alpha (TNF-α) from human B and T cells were significantly increased by extracts, especially bark extract. B or T cell medium, which contains cytokines (IL 6 and TNF-α) secreted by bark extract treatment for 5 days, time-dependently enhanced the growth of NK-92MI cells with the maximal effect at 5th day of incubation. These results suggest that C. macrophylla, especially bark, has the potential for anticancer and immuno-modulatory activities.
Abstract
Anticancer and immuno-modulatory activities of methanol extracts from different parts, bark, wood and leaf, of Cornus macrophylla Wall. were investigated in this study. All extracts at a concentration of 1.0㎎/㎖ showed relativity low cytotoxicities on human normal kidney cell (HEK293) by approximately 25%. Bark extract of C. macrophylla showed the highest anticancer activity on human lung cancer cell line (A549) and human breast cancer cell line (MCF-7) by 57.4% and 58.7%, respectively, at a concentration of 1.0㎎/㎖. All extracts enhanced the growth of human B and T cells, showing 38.7% and 65.9% increase compared to control, respectively, by 5 days incubation with bark extract. The secretions of interleukin 6 (IL6) and tumor necrosis factor alpha (TNF-α) from human B and T cells were significantly increased by extracts, especially bark extract. B or T cell medium, which contains cytokines (IL 6 and TNF-α) secreted by bark extract treatment for 5 days, time-dependently enhanced the growth of NK-92MI cells with the maximal effect at 5th day of incubation. These results suggest that C. macrophylla, especially bark, has the potential for anticancer and immuno-modulatory activities.
참고문헌 (12)
- Cho H, "Study of skin-whitening effects of extract from leaf and bark of Cornus macrephylla", 석사, Graduate School of East-west Medical science, pp.2004
- Doll R, "The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today", J. Natl. Cancer Inst, 66(6), pp.1191~1208 (1981)
- Han BH, "Effect of ginsenosides from Panax ginseng on TNF-α production and T cell proliferation", Yakhak Hoeji, 42(3), pp.296~301 (1998)
- 김종석, "산딸나무열매 추출물의 면역조절기능", 한국약용작물학회지, 10(5), pp.327~332 (2002), 한국약용작물학회
- 권민철, "강화 사자발쑥의 항암활성 증진을 위한 추출조건의 최적화", 한국약용작물학회지, 15(4), pp.233~240 (2007), 한국약용작물학회
- Lee MK, "Enhancement Immune Activity and Cytotoxicity of Artemisia capillaris Thrunb. Extracts against Human Cell Lines", Korean J.Medicinal Crop Sci, 12(1), pp.34~42 (2004)
- 이서호, "황칠나무 잎의 면역활성증진기능 탐색", 한국약용작물학회지, 10(2), pp.109~115 (2002), 한국약용작물학회
- Oh OJ, "Effects on Cellular and humoral immune responses of portulacae herba extract", 석사, pp.1991
- Syed Abdul Qadir, "고로쇠와 우산고로쇠 나무의 부위별 항암 및 면역조절능 비교", 한국약용작물학회지, 15(6), pp.405~410 (2007), 한국약용작물학회
- Yueran Z, "Expression of leptin receptors and response to leptin stimulation of human natural killer cell lines", Biochemical and Biophysical Research Communications, 300, pp.247~252 (2003)
- 곽준수, "산림자원을 이용한 단기 임산물 소득증대 방안", 단기 임산물 소득증대를 위한 심포지엄. 한국임학회. 서울., pp.149~149 (2003)
- 산림식물을 이용한 약제, 건강음료 및 분재용 수목 개발에 관한 연구, "한상섭", 농림부. 과천., 26~26 (2000)