고로쇠와 우산고로쇠 나무의 부위별 항암 및 면역조절능 비교
Comparison of Anticancer and Immuno-Modulatory Activities in the different parts of the Acer mono Max. and Acer okamotoanum
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Abstract
ABSTRACT : This study was performed to investigate anticancer activities and immuno modulatory activities in the several parts of the A. mono and A. okamotoanum. The cytotoxicity of 1㎎/㎖ of the water extracts on normal human lung cell (HEL299) was < 19.5%. The anticancer activity of all extracts were increased in over 55% against AGS (stomach adenocarcinoma), A549 (lung adenocarcinoma), Hep3B (liver adenocarcinoma, and MCF-7 (breast adenocarcinoma) cells. The growth of human immune B and T cells was improved of A. mono and A. okamotoanum in adding 1.0㎎/㎖ concentration. The secretion of the IL-6 and TNF-α of human immune B and T cells was increased with all extracts of A. mono and A. okamotoanum. All extracts of A. mono and A. okamotoanum increased NK cell growth. The results showed that the barks and woods extracts of A. mono and A. okamotoanum had useful biological activities. In addition, bark of A. okamotoanum showed the highest anticancer and immune activities.
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